Table 2 Pharmacological treatment for PFAPA syndrome
Treatment of the episodes | ||
Dose | Remarks | |
Prednisone | 0.5–2 mg/Kg, orally the first day of fever | Possible to repeat on day 2 if fever persists |
Betametasone | 0.2 mg/Kg, orally the first day of fever | Possible to repeat on day 2 if fever persists |
Prophylactic Treatment | ||
Dose | Remarks | |
Colchicine | 0.5–1 mg/daily, orally | Gastro-intestinal side effects |
Cimetidine | 20–40/mg/Kg/daily, orally | Poor efficacy |
Anakinra | 1 mg/Kg, sc the first and second day of fever | Cost-effectiveness |