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Table 2 Pharmacological treatment for PFAPA syndrome

From: PFAPA syndrome: a review on treatment and outcome

Treatment of the episodes
  Dose Remarks
 Prednisone 0.5–2 mg/Kg, orally the first day of fever Possible to repeat on day 2 if fever persists
 Betametasone 0.2 mg/Kg, orally the first day of fever Possible to repeat on day 2 if fever persists
Prophylactic Treatment
  Dose Remarks
 Colchicine 0.5–1 mg/daily, orally Gastro-intestinal side effects
 Cimetidine 20–40/mg/Kg/daily, orally Poor efficacy
 Anakinra 1 mg/Kg, sc the first and second day of fever Cost-effectiveness