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Table 1 Baseline characteristics, VZV disease characteristics and impact on immunosuppressive treatment

From: Clinical course and therapeutic approach to varicella zoster virus infection in children with rheumatic autoimmune diseases under immunosuppression

Baseline characteristics VZV disease characteristics Impact on immunosuppressive treatment
Case Sex/Age (years) Diagnosis Medication at onset of VZV VZV vaccine doses Time to event (months) Date of onset Rash Complications Hosp. Treatment Dur. Management of immunosuppression
Varicella        
  1 F/4.8 JIA MTX 0 15.1 05/2004 typical cellulitis 6d ACV i.v. + AB 7d unknown
  2 F/6.3 JIA MTX 0 14.9 06/2005 typical none no no - continued
  3 F/6.3 JIA MTX 0 14.2 01/2006 typical none no no - continued
  4 F/3.0 JIA MTX 0 6.2 01/2007 typical none no no - continued
  5 F/6.1 JIA MTX + INF 0 17.6 02/2008 typical cellulitis, sepsis 9d ACV i.v. + AB 7d interrupted
  6 F/3.7 JIA ETA 0 4.2 02/2009 typical none no ACV i.v. n.a. interrupted
  7 F/3.4 JIA MTX + ETA 0 8.6 04/2009 typical none no no - interrupted
  8 F/2.5 JIA ETA 0 4.4 03/2010 typical cellulitis no ACV p.o. + AB 7d continued
  9 F/17.4 JIA MTX 1 29.9 10/2010 typical none no no - continued
  10 M/8.9 JIA MTX + ADA 0 21.7 02/2011 typical cerebellitis 5d ACV i.v. 7d continued
  11 M/8.8 JIA MTX + INF 0a 5.7 04/2011 atypical none no no - continued
  12 F/7.2 JIA MTX 0 3 02/2012 typical none 5d ACV i.v. 5d interrupted
  13 F/6.2 JIA MTX + TCZ 0 1.1 03/2012 atypical none no ACV p.o. 8d interrupted
  14 M/4.0 JIA MTX 0 12.4 04/2012 atypical none no VCV p.o. 7d interrupted
  15 M/4.1 JIA TCZ + Pred. 0 3.2 06/2012 typical none 6d ACV i.v. 6d interrupted
  16 M/7.5 JIA MTX + INF 1 30.3 04/2013 atypical none no ACV i.v. + p.o. 7d interrupted
Herpes zoster        
  17 F/6.4 JIA MTX 0 5.5 04/2004 n.a. none no no - continued
  18 F/14.7 JIA MTX + ADA 0 10.9 10/2004 n.a. none no no - continued
  19 F/5.9 JIA MTX 0 4.1 01/2005 n.a. none no no - continued
  20 M/13.6 PAS III RTX + Pred. 0 6 12/2008 n.a. none no no - continued
  21 F/9.5 JIA LEF + INF 0 27.6 07/2011 Lumbar 1, left none no VCV p.o. n.a. interrupted
  22 F/16.5 Ant. Uv. MTX + INF 0 63 11/2013 Trigeminal ophthalmic nerve, left none 4d ACV iv. + p.o.b 7d interrupted
  1. ahad a history of varicella at the age of 6 months. Hosp hospitalization, Dur duration, MTX methotrexate, ETA etanercept, INF infliximab, ADA adalimumab, TCZ tocilizumab, Pred prednisone, VCV valaciclovir, ACV aciclovir, AB antibiotics; balso received local aciclovir. LEF leflunomide, RTX rituximab, JIA juvenile idiopathic arthritis, Ant. uv anterior uveitis, PAS polyglandular autoimmune syndrome, n/a not available