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Table 2 Bethesda System (Last update in 2014)

From: HPV infection and vaccination in Systemic Lupus Erythematosus patients: what we really should know

Terminology Interpretation
Negative for intraepithelial lesion or malignancy No cellular evidence of neoplasia
 Squamous cells:
  Atypical squamous cells:  
   Of undetermined significance (ASC-US) Undetermined
   Cannot exclude HSIL (ASH-H) Cannot exclude pre-malignant lesion
  Low-grade squamous intraepithelial lesion (LSIL) HPV/mild dysplasia/CIN-1
  High-grade squamous intraepithelial lesion (HSIL) Moderate and severe dysplasia/CIN-2 and CIN-3/SIC
  Squamous cell carcinoma Invasive cancer
 Glandular cells:
  Atypical glandular cells Undetermined or cannot exclude pre-malignant lesion
  Endocervical adenocarcinoma is situ CIS
  Adenocarcinoma Invasive cancer
  1. Abbreviations: CIN cervical intraepithelial neoplasia, CIS carcinoma in situ, HPV human papillomavirus
  2. Adapted from Nayar and Wilbu [48]