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Table 5 Factors associated with initial route of MTX Administration in idiopathic uveitis

From: Medication use in juvenile uveitis patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry

    

Multivariable Logistic Regression

Variable

Oral MTX

SQ MTX

Univariate P value

Odds Ratio

95 % CI

P value

N = 31

N = 36

Age at onset, yrs

  

0.06

  

0.61

 Median (IQR)

9.4 (5.7-11.8)

7.1 (5.0-9.3)

    

Gender

  

1.00

  

0.73

 Female

13 (42 %)

15 (42 %)

    

 Male

18 (58 %)

21 (58 %)

    

Ethnicity

  

1.00

  

0.72

 Hispanic

2 (6 %)

2 (6 %)

    

 Non-Hispanic

29 (94 %)

34 (94 %)

    

Race

  

0.046*

12.7

1.5-106.8

0.003*

 Caucasian

27 (87 %)

22 (65 %)

    

 Non-Caucasian

4 (13 %)

12 (35 %)

    

Uveitis type

  

0.65

  

0.51

 Anterior

19 (61 %)

26 (72 %)

    

 Pan

4 (13 %)

5 (14 %)

    

 Intermediate

7 (23 %)

4 (11 %)

    

 Posterior

1 (3 %)

1 (3 %)

    

ANA status

  

1.00

  

0.95

 Positive

11 (44 %)

15 (44 %)

    

 Negative

14 (56 %)

19 (56 %)

    

Complications**

25 (81 %)

28 (80 %)

1.00

  

0.73

 Cataracts

15 (48 %)

16 (44 %)

0.81

  

0.94

  1. Data in this table include subject characteristics associated with the route of methotrexate administration initially prescribed
  2. IQR interquartile range, SQ subcutaneous, CI confidence interval, ANA antinuclear antibody
  3. *Statistically significant, **Presence of at least one ocular complication