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Table 5 Factors associated with initial route of MTX Administration in idiopathic uveitis

From: Medication use in juvenile uveitis patients enrolled in the Childhood Arthritis and Rheumatology Research Alliance Registry

     Multivariable Logistic Regression
Variable Oral MTX SQ MTX Univariate P value Odds Ratio 95 % CI P value
N = 31 N = 36
Age at onset, yrs    0.06    0.61
 Median (IQR) 9.4 (5.7-11.8) 7.1 (5.0-9.3)     
Gender    1.00    0.73
 Female 13 (42 %) 15 (42 %)     
 Male 18 (58 %) 21 (58 %)     
Ethnicity    1.00    0.72
 Hispanic 2 (6 %) 2 (6 %)     
 Non-Hispanic 29 (94 %) 34 (94 %)     
Race    0.046* 12.7 1.5-106.8 0.003*
 Caucasian 27 (87 %) 22 (65 %)     
 Non-Caucasian 4 (13 %) 12 (35 %)     
Uveitis type    0.65    0.51
 Anterior 19 (61 %) 26 (72 %)     
 Pan 4 (13 %) 5 (14 %)     
 Intermediate 7 (23 %) 4 (11 %)     
 Posterior 1 (3 %) 1 (3 %)     
ANA status    1.00    0.95
 Positive 11 (44 %) 15 (44 %)     
 Negative 14 (56 %) 19 (56 %)     
Complications** 25 (81 %) 28 (80 %) 1.00    0.73
 Cataracts 15 (48 %) 16 (44 %) 0.81    0.94
  1. Data in this table include subject characteristics associated with the route of methotrexate administration initially prescribed
  2. IQR interquartile range, SQ subcutaneous, CI confidence interval, ANA antinuclear antibody
  3. *Statistically significant, **Presence of at least one ocular complication