Table 1 American College of Rheumatology biopsy guidelines (adapted from Table 2 in reference 2)

1)

Increasing serum creatinine without compelling alternative cause^a, or

2)

Confirmed proteinuria of ≥ 1 g per 24-hrs^b, or

3)

Combinations of the following, assuming the findings are confirmed within a short period of time and in the absence of alternative causes:

•

Proteinuria ≥ 0.5 g per 24-hrs^b plus hematuria^c, or

•

Proteinuria ≥ 0.5 g per 24-hrs^bplus cellular casts.