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Figure 3 | Pediatric Rheumatology

Figure 3

From: Increased soluble phagocytic receptors sMer, sTyro3 and sAxl and reduced phagocytosis in Juvenile-onset Systemic Lupus Erythematosus

Figure 3

CD14+ Mer levels and plasma sMer, sTyro and sAXL concentration in JSLE, JIA and control patients. Levels of cell surface Mer were analysed in JSLE (n = 6), JIA (n = 6) and control (n = 6) patient monocytes (A). Mer was found to be significantly decreased in JSLE monocytes compared to healthy control monocytes (A; p = 0.026). JSLE (n = 15), JIA (n = 10) and control (n = 15) patient plasma was analysed by ELISA for sMer concentrations (B). JSLE patients had significantly higher levels of plasma sMer in comparison to JIA and control plasma (B; p = 0.014 and p < 0.001 respectively). In addition JIA patients had significantly increased levels of plasma sMer in comparison to healthy controls (B; p = 0.001). JSLE (n = 30), JIA (n = 20) and control (n = 30) patient plasma was analysed by ELISA for sTyro3 concentrations (C). JSLE patients had significantly higher plasma levels of sTyro3 in comparison to JIA and control patients (C; p = 0.004 and p = 0.021 respectively). JSLE (n = 14), JIA (n = 12) and control (n = 14) patient plasma was analysed by ELISA for sAxl concentrations (D). JSLE patients had significantly higher plasma levels of sAxl in comparison to JIA and control patients (D; p = 0.0009 and p = 0.0041 respectively). BILAG score is significantly correlated with JSLE plasma sAxl concentration (E; p = 0.0032). Data are shown as the mean ± SEM and a Mann-Whitney U test was performed to determine significance values.

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