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Table 1

From: Various aspects of Kikuchi disease in three children: systemic or self-limited disease?

  Patient 1 Patient 2 Patient 3
Age (years) 5 17 9
Underlying disease Non complicated sickle cell anemia Severe sickle cell anemia None
Symptoms - Left cervical lymphadenopathy
- Intermittent fever
- Intermittent fever
- Maculo-papules
- Fatigue
- Painful cervical and inguinal adenopathies
- Headaches
- Polyarthritis
- Prolonged fever
- Intermittent tonsillitis
- Bilateral painful cervical lymph nodes
Biological features - Mild inflammation
- Elevated LDH
- Marked inflammation
- Pancytopenia
- Auto-immune anemia
- Auto-immune hepatitis
- No ANA
- Marked inflammation
- Leucopenia
Biopsy Cervical lymph node excisional biopsy Cervical lymph node excisional biopsy Tonsillectomy
Treatment None - Steroids for 7 months
- Azathioprine
- Methotrexate
None
Outcome Spontaneous resolution after 4 months Progressive regression of clinical and biological signs with resolution of auto-immunity Spontaneous resolution 2 months after tonsillectomy