| Sensitivity (%) With 95%CI | Specificity (%) With 95% CI | PPV (%) With 95% CI |
---|---|---|---|
Anti-Citrullinated Fibrinogen Antibodies (> 0.59OD) | Â | Â | Â |
   Overall | 32.3 (23.3-42.7) | 84.2 (59.5-95.8) | 91.2 (75.2-97.7) |
   Poly RF-positive | 81.3 (53.7-95.0) | 78.8 (69.2-86.1) | 38.2 (22.7-56.4) |
   Poly RF-negative | 30.6 (16.9-48.3) | 70.9 (59.4-80.3) | 32.4 (18.0-50.6) |
   Oligoarthritis | 24.0 (10.2-45.5) | 68.9 (58.1-78.0) | 17.6 (7.4-35.0) |
   Systemic-Onset | 7.7 (0.4-37.9) | 67.6 (57.6-76.4) | 29.4 (0.1-17.1) |
Anti-Citrullinated α-Enolase Antibodies (> 0.91OD) |  |  |  |
   Overall | 9.4 (4.6-17.5) | 57.9 (34.0-78.9) | 52.9 (28.5-76.1) |
   Poly RF-positive | 18.8 (5.0-46.3) | 85.9 (77.1-91.8) | 17.6 (4.6-44.2) |
   Poly RF-negative | 5.6 (1.0-20.0) | 70.9 (59.4-80.3) | 11.8 (2.1-37.7) |
   Oligoarthritis | 0 | 81.1 (71.2-88.3) | 0 |
   Systemic-Onset | 7.7 (0.4-37.9) | 84.3 (75.5-90.5) | 5.9 (0.3-31.0) |
IgG anti-CCP antibodies (> 20U) | Â | Â | Â |
   Overall | 14.6 (8.5-23.6) | 94.7 (71.9-99.7) | 93.3 (66.0-99.7) |
   Poly RF-positive | 56.3 (30.6-79.2) | 93.9 (86.8-97.5) | 60.0 (32.9-82.5) |
   Poly RF-negative | 13.9 (5.2-30.3) | 87.3 (77.5-93.4) | 33.3 (13.0-61.3) |
   Oligoarthritis | 0 | 83.3 (73.7-90.0) | 0 |
   Systemic-Onset | 0 | 85.3 (76.6-91.2) | 0 |
IgA anti-CCP antibodies (> 0.16OD) | Â | Â | Â |
   Overall | 10.4 (5.4-18.7) | 84.2 (59.5-95.8) | 76.9 (46.0-93.8) |
   Poly RF-positive | 25.0 (8.3-52.6) | 90.9 (83.0-95.5) | 30.8 (10.3-61.1) |
   Poly RF-negative | 16.7 (6.9-33.5) | 91.1 (82.0-96.1) | 46.2 (20.4-73.9) |
   Oligoarthritis | 0 | 85.6 (76.2-91.8) | 0 |
   Systemic-Onset | 0 | 87.3 (78.8-92.8) | 0 |
IgM Anti-CCP Antibodies (> 0.45OD) | Â | Â | Â |
   Overall | 16.7 (10.1-26.0) | 73.7 (48.6-89.9) | 76.2 (52.5-90.9) |
   Poly RF-positive | 31.3 (12.1-58.5) | 83.8 (74.8-90.2) | 23.8 (9.1-47.5) |
   Poly RF-negative | 16.7 (6.9-33.5) | 91.1 (82.0-96.1) | 46.2 (20.4-73.9) |
   Oligoarthritis | 0 | 76.7 (66.3-84.7) | 0 |
   Systemic-Onset | 7.7 (0.4-37.9) | 80.4 (71.1-87.3) | 4.8 (0.2-25.9) |
IgA RF (> 6U) | Â | Â | Â |
   Overall | 15.6 (9.3-24.8) | 84.2 (59.5-95.8) | 83.3 (57.7-95.6) |
   Poly RF-positive | 62.5 (35.9-83.7) | 91.9 (84.2-96.2) | 55.6 (31.3-77.6) |
   Poly RF-negative | 11.1 (3.6-27.0) | 82.2 (71.7-89.6) | 22.2 (7.4-48.1) |
   Oligoarthritis | 0 | 80.0 (70.0-87.4) | 0 |
   Systemic-Onset | 7.7 (0.4-37.9) | 83.3 (74.4-89.7) | 5.6 (0.3-29.4) |
IgM RF (> 6U) | Â | Â | Â |
   Overall | 47.9 (37.7-58.3) | 63.1 (38.6-82.8) | 86.8 (74.0-94.1) |
   Poly RF-positive | 100.0 (75.9-100.0) | 62.6 (52.3-72.0) | 30.2 (18.7-44.5) |
   Poly RF-negative | 47.2 (30.8-64.7) | 54.4 (42.9-65.5) | 32.1 (20.3-46.4) |
   Oligoarthritis | 20.0 (7.6-41.3) | 46.7 (36.2-57.4) | 9.4 (3.5-21.4) |
   Systemic-Onset | 61.5 (32.3-84.9) | 55.9 (45.7-65.6) | 15.1 (7.2-28.1) |