Figure 1

Timeline of Response to Therapy. Time in weeks after the onset of first symptoms of HSP is shown on the horizontal axis. The vertical axis shows serum creatinine in mg/dl (red), and therapeutic measures used. The daily dose of glucocorticoid in mg/kg/day is in blue; methylprednisolone pulse therapy is represented by blue arrows (30 mg/kg/day for 5 days, each arrow); and in the upper portion of the figure, anakinra dose is illustrated. Note that the serum creatinine rose when the anakinra dose was decreased, both at week eleven and at week thirty.