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Table 1 "Occasional" and "Frequent" NSAID Side Effects Reported by Rheumatologists

From: Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data

Side Effect number reported, (% of total) Traditional (n = 99) COX-2 (n = 95) p-value
Abdominal Pain 80 (81) 22 (23) < .001
Gastric/duodenal ulcer 6 (6) 2 (2) 0.28
Hematuria 4 (4) 1 (1) 0.37
Hypertension 3 (3) 3 (3) 1.0
Thrombocytopenia 1 (1) 0 (0) 1.0
Epistaxis 13 (13) 2 (2) .006
Easy Bruising 63 (64) 8 (8) < .001
Headache 21 (21) 1 (1) < .001
Fatigue 12 (12) 1 (1) .003
  1. "occasional" = reported more than once per month, "frequent" = reported more than once per week, COX = cyclooxygenase. Only pediatric rheumatologists who prescribed these drugs were included, therefore, the sample sizes of the comparison groups were different. Statistical comparisons were made by Fisher's exact test.