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Table 1 "Occasional" and "Frequent" NSAID Side Effects Reported by Rheumatologists

From: Nonsteroidal Anti-Inflammatory Drugs: A survey of practices and concerns of pediatric medical and surgical specialists and a summary of available safety data

Side Effect number reported, (% of total)

Traditional (n = 99)

COX-2 (n = 95)

p-value

Abdominal Pain

80 (81)

22 (23)

< .001

Gastric/duodenal ulcer

6 (6)

2 (2)

0.28

Hematuria

4 (4)

1 (1)

0.37

Hypertension

3 (3)

3 (3)

1.0

Thrombocytopenia

1 (1)

0 (0)

1.0

Epistaxis

13 (13)

2 (2)

.006

Easy Bruising

63 (64)

8 (8)

< .001

Headache

21 (21)

1 (1)

< .001

Fatigue

12 (12)

1 (1)

.003

  1. "occasional" = reported more than once per month, "frequent" = reported more than once per week, COX = cyclooxygenase. Only pediatric rheumatologists who prescribed these drugs were included, therefore, the sample sizes of the comparison groups were different. Statistical comparisons were made by Fisher's exact test.