Table 1 Pediatric Cases of Bulllous SLE

Jacoby & Abraham 1979³

Male

15 years

Multiple tense vesicles and bullae, arising on normal skin on the face, chest, axilla and inner arm

Subepidermal blister with neutrophils, eosinophils and lymphocytes.

DIF^¥ IgG depositis in the BMZ^£ under and around the vesicle

Hall et al 1982⁴

Male

12 years

Small vesicles on an erythematous base on arms, face, chest and legs.

Subepidermal bullae with neutrophilic microabscesses in dermal papillary tips.

DIF: linear IgG, IgA, IgM and IgE and granular C3 deposits at the dermo-epidermal junction.

Kettler et al 1988⁵

Female

8 years

Bullous tense eruption over the face, hairline, neck, axilla, groin, ankles, palms and soles.

Subepidermal bullae with neutrophilic infiltrate as well as papillary microabscesses adjacent to the bulla.

DIF: Granular IgG and C3 deposits at the dermo-epidermal junction

Roholt et al 1995⁶

Female

9 years

Linear papulovesicular eruption over the right dorsal hand and ulnar forearm.

Subepidermal split, mixed cellular infiltrate with neutrophils.

DIF: strong IgG, IgA and IgM linear deposition at the dermo-epidermal junction

Shirhama et al 1998⁷

Female

9 years

Widespread blisters on the trunk, neck, and oral mucosa.

Subepidermal blister with a neutrophilic infiltrate in the upper dermis.

DIF: linear IgG, IgA and C3 deposition at the BMZ.

Chan et al 1999⁸

Female

15 years

Numerous tense bulla on her entire skin surface

Subepidermal blister, neutrophilic infiltrate in papillary dermis and blister cavity.

DIF: IgG, IgA and C3 deposits at the BMZ.

Nitta Y et al 2002⁹

Male

17 years

Disseminated blistering eruption

Papillary microabscesses of neutrophils and subepidermal blisters.

DIF: IgG, IgA, IgM and C3 deposits at the BMZ.

Harris-Stith et al 2003¹⁰

Female

17 years

Photodistributed tense bulla on the face (lips and ears) and upper torso, as well as oral and vaginal erosions

Neutrophil-rich subepidermal bullae.

DIF: IgG, IgM and C3 deposits at the dermo-epidermal junction

Sirka et al 2005¹¹

Female

18 years

Vesicles on the left retroauricular area, left upper eyelid, right axilla, chest and abdomen.

Subepidermal bullae with neutrophilic microabscesses.

No DIF was performed.

Vijayalkshmi & Jayavardhana 2007¹²

Male

10 years

Vesicles and bulla on ears, neck, shoulders, arms and legs

Subepidermal blister with neutrophilic dermal infiltration.

DIF: strong IgG and moderately strong IgM, IgA and C3 granular BMZ deposition.

Kumar &Agarwal¹³

Female

13 years

Numerous bulla and vesicles on the back, abdomen, neck, flexures of the arm and groin.

Dermo-epidermal separation and a neutrophil-predominant inflammatory infiltrate in the upper dermis.

DIF: Prominent fluorescence along the epidermal basement membrane for IgG, IgA, IgM and C3.