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Table 1 Pediatric Cases of Bulllous SLE

From: Bullous lesions as a manifestation of systemic lupus erythematosus in two Mexican teenagers

Author & Year Sex Age Clinical features Histopathological features
Jacoby & Abraham 19793 Male 15 years Multiple tense vesicles and bullae, arising on normal skin on the face, chest, axilla and inner arm Subepidermal blister with neutrophils, eosinophils and lymphocytes.
     DIF¥ IgG depositis in the BMZ£ under and around the vesicle
Hall et al 19824 Male 12 years Small vesicles on an erythematous base on arms, face, chest and legs. Subepidermal bullae with neutrophilic microabscesses in dermal papillary tips.
     DIF: linear IgG, IgA, IgM and IgE and granular C3 deposits at the dermo-epidermal junction.
Kettler et al 19885 Female 8 years Bullous tense eruption over the face, hairline, neck, axilla, groin, ankles, palms and soles. Subepidermal bullae with neutrophilic infiltrate as well as papillary microabscesses adjacent to the bulla.
     DIF: Granular IgG and C3 deposits at the dermo-epidermal junction
Roholt et al 19956 Female 9 years Linear papulovesicular eruption over the right dorsal hand and ulnar forearm. Subepidermal split, mixed cellular infiltrate with neutrophils.
     DIF: strong IgG, IgA and IgM linear deposition at the dermo-epidermal junction
Shirhama et al 19987 Female 9 years Widespread blisters on the trunk, neck, and oral mucosa. Subepidermal blister with a neutrophilic infiltrate in the upper dermis.
     DIF: linear IgG, IgA and C3 deposition at the BMZ.
Chan et al 19998 Female 15 years Numerous tense bulla on her entire skin surface Subepidermal blister, neutrophilic infiltrate in papillary dermis and blister cavity.
     DIF: IgG, IgA and C3 deposits at the BMZ.
Nitta Y et al 20029 Male 17 years Disseminated blistering eruption Papillary microabscesses of neutrophils and subepidermal blisters.
     DIF: IgG, IgA, IgM and C3 deposits at the BMZ.
Harris-Stith et al 200310 Female 17 years Photodistributed tense bulla on the face (lips and ears) and upper torso, as well as oral and vaginal erosions Neutrophil-rich subepidermal bullae.
     DIF: IgG, IgM and C3 deposits at the dermo-epidermal junction
Sirka et al 200511 Female 18 years Vesicles on the left retroauricular area, left upper eyelid, right axilla, chest and abdomen. Subepidermal bullae with neutrophilic microabscesses.
     No DIF was performed.
Vijayalkshmi & Jayavardhana 200712 Male 10 years Vesicles and bulla on ears, neck, shoulders, arms and legs Subepidermal blister with neutrophilic dermal infiltration.
     DIF: strong IgG and moderately strong IgM, IgA and C3 granular BMZ deposition.
Kumar &Agarwal13 Female 13 years Numerous bulla and vesicles on the back, abdomen, neck, flexures of the arm and groin. Dermo-epidermal separation and a neutrophil-predominant inflammatory infiltrate in the upper dermis.
     DIF: Prominent fluorescence along the epidermal basement membrane for IgG, IgA, IgM and C3.
  1. ¥ DIF = Direct Immunofluorescence; £ BMZ= Basal membrane zone