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Table 1 Correlation between exposure (12-hour AUC determined by full 10-point PK profile, calculated using the trapezoid rule) and individual time concentration points.

From: Random pharmacokinetic profiles of EC-MPS in children with autoimmune disease

Parameter C0 C0.5 C1 C1.5 C2 C3 C4 C6 C8 C12
Number of XY Pairs 7 7 7 7 7 7 7 7 7 7
Spearman r 0.3929 0.7500 0.2162 0.2162 0.8571 0.7857 0.8571 0.9190 0.6786 0.6786
P value (two-tailed) 0.3956 0.0663 0.6615 0.6615 0.0238 0.0480 0.0238 0.0067 0.1095 0.1095
   P value summary ns ns ns ns * * * ** ns ns
   Exact or approximate P value? Exact Exact Exact Exact Exact Exact Exact Exact Exact Exact
   Is the correlation significant? (alpha = 0.05) No No No No Yes Yes Yes Yes No No
  1. Only C6 correlated with AUC.