Table 1 Correlation between exposure (12-hour AUC determined by full 10-point PK profile, calculated using the trapezoid rule) and individual time concentration points.
From: Random pharmacokinetic profiles of EC-MPS in children with autoimmune disease
Parameter | C0 | C0.5 | C1 | C1.5 | C2 | C3 | C4 | C6 | C8 | C12 |
|---|---|---|---|---|---|---|---|---|---|---|
Number of XY Pairs | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 | 7 |
Spearman r | 0.3929 | 0.7500 | 0.2162 | 0.2162 | 0.8571 | 0.7857 | 0.8571 | 0.9190 | 0.6786 | 0.6786 |
P value (two-tailed) | 0.3956 | 0.0663 | 0.6615 | 0.6615 | 0.0238 | 0.0480 | 0.0238 | 0.0067 | 0.1095 | 0.1095 |
P value summary | ns | ns | ns | ns | * | * | * | ** | ns | ns |
Exact or approximate P value? | Exact | Exact | Exact | Exact | Exact | Exact | Exact | Exact | Exact | Exact |
Is the correlation significant? (alpha = 0.05) | No | No | No | No | Yes | Yes | Yes | Yes | No | No |