Treatment of osteogenesis imperfecta with intravenous pamidronate in pediatric patients: comparison between a single-day infusion twice a year protocol with other regimens described in the literature

Table 1 Comparison between our protocol and the ones published by Glorieux and Arikoski

	HSJD	Glorieux [1]	Arikoski [2]
Patients	20	30	12
Dose (mg/Kg/year)	2.4(0.3)	6.8(1.1)	12
Periodicity of infusions (m)	6	3–4	3
Basal z-score	-4.3(2)	-5.3(1.2)	*
Final z-score	-3.38(2.4) **	-3.4(1.5)	*
Years of treatment	3**	2.1(range 1.3–5)	1
Mean annual increase in: z-score BMD	0.49 (0.1) 21.1 (5.1)	0.95 41.9 (29)	* 63.5(37.3)

Mean(SD). m: months. *Data not available. ** For comparability with the other series only the results of the first 3 years are shown.

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