Elevated serum levels of soluble CD154 in children with juvenile idiopathic arthritis

Table 4 Cytokine levels in sera of healthy controls and in patients with different JIA subtypes.

Cytokine	Controls N = 130	Systemic N = 10	Poly RF+ N = 10	Poly RF- N = 14	Persistent oligo N = 20	Extended Oligo N = 11	ERA N = 11
IL1β	0.6 (0–143)	6.8 (3–407)^§	100.4 (0–1000)^§	13.4 (0–1000)^§	5.6 (0–289)^†	29.7 (0–1000)^‡	6.3 (1–656)^†
IL6	0.6 (0–19)	34.2 (3–980)^§	36 (1–1000)^§	17 (0.9–1000)^§	7.6 (1–1000)^§	5.6 (1–1000)^§	14.2 (2–99)^§
IL8	2 (0–9)	14.2 (0–103)^‡	62.6 (0–1000)^§	63.3 (0–1000)^†	12.4 (0–380)^§	20.3 (0–1000)	0 (0–81)
IL10	2.0 (0–32)	6.7 (1–46)*	7.1 (1–40)*	3.9 (1–14)*	1.8 (0–42)	1.8 (0–10)	2.7 (1–76)
IL13	0.8 (0–15)	0 (0–427)	83.3 (0–1152)^‡	48.4 (0–980)^†	0 (0–1300)*	19 (0–396)*	19.4 (0–1367)*
sCD154	19 (0–599)	327 (89–609)^§	408 (35–2382)^§	203 (40–596)^§	180 (0–390)*	180 (60–360)^§	379 (57–2996)^§
sIL2R	785 (180–1505)	1184 (703–3000)^‡	1057 (174–2662)*	1355 (176–3000)*	501 (100–1762)	895 (273–2173)	822 (361–3000)
TNFα	0 (0–233)	22.8 (0–335)^§	47.6 (0–564)^§	24.3 (0–498)^§	0 (0–191)*	66.8 (0–435)^§	15 (0–1000)^§

Poly RF+, rheumatoid factor positive polyarticular JIA; Poly RF-, rheumatoid factor negative polyarticular JIA; oligo, oligoarticular JIA; ERA, enthesitis related arthritis; IL, Interleukin; sCD154, soluble CD154; sIL2R, soluble IL2 receptor; TNFα, tumor necrosis factor-α;
All values median (range) are expressed in pg/ml. Values of sIL2R and sCD40L levels, as well as ranges of all cytokines have been rounded to the nearest number.
* Significant difference between controls and patients; p < 0.05.
‡ Significant difference between controls and patients; p < 0.01
† Significant difference between controls and patients; p < 0.001;
§Significant difference between controls and patients; p < 0.0001.

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