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Table 1 Delphi 2 Responses in order of descending number of votes

From: Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus

PROBLEM TREATMENT VOTES
Systemic onset juvenile rheumatoid arthritis Anti-IL-6 receptor antibody 62
Uveitis (juvenile rheumatoid arthritis, sarcoid, or idiopathic) unresponsive to methotrexate Infliximab 50
Pediatric systemic lupus erythematosus Mycophenolate mofetil 48
Thrombocytopenia unresponsive to standard therapy in systemic lupus erythematosus Rituximab 47
Juvenile dermatomyositis unresponsive to prednisone and disease-modifying anti-rheumatic drugs Enbrel 43
Systemic onset juvenile rheumatoid arthritis Thalidomide 43
Systemic onset juvenile rheumatoid arthritis Anakinra 36
Localized scleroderma Combination: steroids and methotrexate 35
Juvenile dermatomyositis unresponsive to prednisone and disease-modifying anti-rheumatic drugs Infliximab 29
Rash of juvenile dermatomyositis Topical tacrolimus 27
Systemic lupus erythematosus proliferative nephritis unresponsive to pulse cyclophosphamide and mycophenolate mofetil Combination: pulse cyclophosphamide and mycophenolate mofetil 25
Chronic Recurrent Multifocal Osteomyelitis that is not controlled by non-steroid anti-inflammatory drugs and/or that requires corticosteroids Bisphosphonates 24
Localized scleroderma Methotrexate orally 20
Linear scleroderma refractory to oral or subcutaneous methotrexate treatment Oral mycophenolate mofetil treatment 19
Henoch Scholein Purpura Glucocorticoid treatment 18
Osteoporosis Alendronate and other possibilities 18
Pauciarticular juvenile rheumatoid arthritis Intraarticular steroids 17
Systemic onset juvenile rheumatoid arthritis Combination:TNF blockers and thalidomide 17
Behcet's Infliximab 16
Early polyarticular juvenile rheumatoid arthritis CTLA4-1g 16
Macrophage activation syndrome Combination: cyclosporin + corticosteroids 15
Sarcoid arthritis Enbrel 15
Severe systemic lupus erythematosus – cyclophosphamide dependent or resistant Intravenous fludarabine 15
Rash of systemic lupus erythematosus Topical tacrolimus 14
Acute rheumatic fever Naproxen 13
Henoch Scholein Purpura with abdominal pain Glucocorticoid treatment 13
Juvenile rheumatoid arthritis-temporomandibular joint arthritis Corticosteroid joint injections 13
Systemic onset juvenile rheumatoid arthritis Oral intravenous immunoglobulin as adjuvant therapy 10
Familial Mediterranean fever not responsive to colchicine Anakinra 8
Refractory iritis in juvenile rheumatoid arthritis Cyclosporin 8
Osteoporosis Vitamin D – the various preparations 7
Raynaud's 10 and 20 Biofeedback 7
Familial Mediterranean fever Anti-Interleukin 1 5
Systemic onset juvenile rheumatoid arthritis Combination: hydroxychloroquine and standard therapy 2
Systemic onset juvenile rheumatoid arthritis Combination: thalidomide and cyclosporin 2