Regulatory T cells and their role in rheumatic diseases: a potential target for novel therapeutic development

Table 1 Characteristics of IPEX Syndrome ^#§.

Organ system	Manifestations*
Endocrine	Insulin dependent diabetes mellitus Thyroid dysfunction Parathyroid hormone resistance
Gastrointestinal	Autoimmune enteropathy Diarrhea Villous atrophy, failure to thrive
Skin	Eczema Ichthyosiform dermatitis Exfoliative dermatitis
Infectious disease	Exaggerated response to viral infections Frequent infections
Immune dysregulation	Increased IgE, intermittent eosinophilia Skewing of T lymphocytes to Th2 phenotype Hemolytic anemia Immune thrombocytopenia Coagulopathy

^# Alternative names: XLAAD (X-linked autoimmunity allergic dysregulation syndrome); insulin dependent diabetes mellitus-secretory diarrhea syndrome; XPID (Polyendocrinopathy, immune dysfunction, diarrhea, X-linked)
^§ Treatment: immunosuppression (Cyclosporine A), allogeneic bone marrow transplantation
* Manifestations of the disease are highly variable

ISSN: 1546-0096