Figure 4
From: Neutrophils: the forgotten cell in JIA disease pathogenesis
Aberrant patterns of neutrophil NAD(P)H oscillation in JRA neutrophils. JRA patients express a small population (10–30% of the cells) that are MPO-positive and show both frequency and amplitude enhancement of NAD(P)H oscillations triggered by frequency-modulating LPS. These findings demonstrate a breakdown in the fundamental metabolic pathways regulating neutrophil oscillatory activities in JRA patients. From Jarvis et al, Arthritis Res Therapy 2006. The authors retain the copyright for this material.