Table 1
Parameter | 694 Homozygous (N=57) | Other mutations (N=56) | P |
|---|---|---|---|
Average length of attack (days) | 2.66±1.5 | 3.03±1.2 | 0.073 |
Abdominal attacks | 50 (87.7%) | 48 (85.7%) | 0.788 |
Arthritis attacks | 52 (91.3%) | 28 (50%) | <0.0001 |
Pleuritis attacks | 36 (46.2%) | 18 (38.2%) | 0.0013 |
Exertional leg-pain | 47 (82.5%) | 36 (64.3%) | 0.034 |
ELE attacks | 10 (17.5%) | 3 (5.4%) | 0.073 |
Attacks of fever alone | 20 (35.1%) | 12 (21.4%) | 0.143 |
Average colchicine dose (mg/day) | 1.9±0.48 | 1.48±0.54 | 0.0001 |
IV colchicine treatment | 5 (8.8%) | 0 (0%) | 0.057 |
Proteinuria or amyloidosis | 6 (10.5%) | 1 (1.8%) | 0.113 |
Anemia of chronic disease | 14/53 (26.4%) | 7/52 (13.5%) | 0.142 |
Elevated acute phase reactants | 10/18 (55.6%) | 4/16 (25%) | 0.092 |
Chronic renal failure | 6 (10.5%) | 0 (0%) | 0.027 |
Chronic arthritis | 11 (19.3%) | 2 (3.6%) | 0.015 |
Work days lost each month | 4.4±7.2 | 2.6±4.6 | 0.718 |
Harm to quality of life | (1-10) 5.6±3.3 | 4.1±3 | 0.013 |
Number of attacks per year w colchicine | 7.2±7.8 | 3.5±5.5 | 0.0007 |
Number of attacks per year w/o colchicine | 23.6±9.3 | 15.6±11.7 | 0.0001 |
Crohn's disease | 4 (7%) | 2 (3.6%) | 0.679 |
Ankylosing Spondylitis | 3 (5.3%) | 1 (1.8%) | 0.619 |
Behcet's Disease | 7 (12.3%) | 1 (1.8%) | 0.061 |
Henoch Schonlein Purpura | 1 (1.8%) | 0 | 1 |
All FMF associated diseases | 17 (29.8%) | 7 (12.5%) | 0.0373 |