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Table 1 CLARITY association replication results

From: Independent confirmation of juvenile idiopathic arthritis genetic risk loci previously identified by immunochip array analysis

Gene

SNP

Minor allele

Case MAF/Control MAF

 

Allelic

Best

Immunochip

Replicationc

P

OR (95% CI)

Pa

Pb

OR (95% CI)

13q14

rs34132030

T

0.30/0.30

0.82

1.02 (0.85-1.24)

0.68 D

1.77 × 10-7 A

1.18(1.11-1.26)

N

AFF3-LONRF2

rs6740838

T

0.44/0.41

0.25

1.11 (0.93-1.32)

0.042 R

8.83 × 10-7 D

1.25(1.14-1.37)

Y

ANKRD55

rs71624119

A

0.20/0.23

0.10

0.83 (0.67-1.03)

0.081 R

4.40 × 10-11 A

0.78(0.73-0.84)

S

ATP8B2-IL6R

rs11265608

A

0.08/0.07

0.50

1.12 (0.81-1.55)

0.50 T

2.75 × 10-8 D

1.33(1.20-1.47)

N

C5orf56-IRF1

rs4705862

T

0.42/0.45

0.11

0.87 (0.73-1.04)

0.033 D

1.02 × 10-8 A

0.84(0.79-0.89)

Y

CCR1-CCR3

rs79893749

T

0.09/0.11

0.10

0.78 (0.58-1.05)

0.10 A

1.88 × 10-7 A

0.78(0.72-0.86)

S

ERAP2-LNPEP

rs27290

G

0.47/0.39

0.00021

1.40 (1.17-1.66)

0.00021 A

7.50 × 10-9 D

1.32(1.20-1.45)

Y

FAS

rs7069750

G

0.47/0.45

0.19

1.12 (0.94-1.34)

0.19 A

2.93 × 10-8 A

1.18(1.11-1.25)

S

IL2-IL21

rs1479924

G

0.27/0.28

0.54

0.94 (0.77-1.15)

0.16 R

6.24 × 10-11 A

0.79(0.74-0.85)

S

IL2RB

rs2284033

A

0.40/0.43

0.24

0.90 (0.75-1.08)

0.18 D

1.55 × 10-8 A

0.84(0.79-0.89)

S

IL6

rs7808122

T

0.41/0.40

0.76

1.03 (0.86-1.23)

0.59 R

5.80 × 10-8 A

1.19(1.11-1.25)

N

JAZF1

rs10280937

C

0.15/0.14

0.77

1.04 (0.81-1.33)

0.74 D

6.60 × 10-7 A

1.25(1.15-1.37)

N

LTBR

rs2364480

C

0.26/0.27

0.65

0.96 (0.78-1.16)

0.49 R

5.10 × 10-8 A

1.20(1.12-1.28)

N

PRR5L

rs4755450

A

0.34/0.38

0.043

0.83 (0.69-0.99)

0.042 D

3.35 × 10-7 D

0.80(0.74-0.87)

Y

RUNX1

rs9979383

C

0.32/0.37

0.013

0.79 (0.66-0.95)

0.013 A

1.06 × 10-8 D

0.78(0.72-0.85)

Y

RUNX3

rs4648881

A

0.48/0.50

0.37

0.92 (0.78-1.10)

0.19 D

4.66 × 10-7 A

1.16(1.10-1.23)

S*

TYK2

rs34536443

C

0.02/0.03

0.10

0.63 (0.36-1.10)

0.10 A

1.00 × 10-10 A

0.56(0.47-0.67)

S

UBE2L3

rs2266959

T

0.23/0.19

0.040

1.25 (1.01-1.55)

0.036 T

6.20 × 10-9 D

1.24(1.15-1.33)

Y

ZFP36L1

rs12434551

T

0.46/0.45

0.61

1.05 (0.88-1.25)

0.50 R

1.59 × 10-8 D

0.77(0.71-0.85)

N

  1. aModel providing most significant P value: A = allelic, D = dominant, G = genotypic, R = recessive, T = trend (Cochrane-Armitage Trend Test, also referred to as additive).
  2. bImmunochip model: A = additive, D = dominant.
  3. cEvidence for replication Y = yes N = no S = suggestive * = opposite direction of effect due to the minor allele being opposite between the two studies.
  4. Bold = reached genome-wide significance in Immunochip paper.