Predictors of response to methotrexate in juvenile idiopathic arthritis

Table 2 Final logistic regression models for PedACR 30 at month 3 and PedACR70 at month 12 with adjusted odds ratios

Determinants of response	OR (95% CI)	p-value
*PedACR 30 at month 3*
No. of tender joints*	0.92 (0.88-0.97)	0.002
No. of active joints*	1.26 (1.16-1.36)	<0.001
Parents global assessment of overal well-being [VAS 0-100 mm]*	1.02 (1.01-1.03)	<0.001
Concomitant use of NSAIDs	1.89 (1.08-3.34)	0.027
Model performance:
AUC	73.6%
Sensitivity	98.7%
Specificity	12.4%
*Ped ACR70 at month 12*
Disease duration >1 year	0.54 (0.39-0.77)	0.001
No. of tender joints*	0.92 (0.88-0.97)	<0.001
No. of active joints*	1.10 (1.05-1.16)	<0.001
Parent’s global assessment of child’s pain [VAS 0-100 mm]*	1.01 (1.00-1.01)	0.029
Presence of morning stiffness	1.58 (1.10-2.28)	0.014
Model performance:
AUC	67.2%
Sensitivity	90.7%
Specificity	27.0%

Specificity = probability for non-responders being correctly identified by the model, sensitivity = likewise defined probability for responders. AUC = area under the curve, OR = odd’s ratio, *per increment of 1 unit.

ISSN: 1546-0096