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Table 2 Final logistic regression models for PedACR 30 at month 3 and PedACR70 at month 12 with adjusted odds ratios

From: Predictors of response to methotrexate in juvenile idiopathic arthritis

Determinants of response OR (95% CI) p-value
PedACR 30 at month 3
No. of tender joints* 0.92 (0.88-0.97) 0.002
No. of active joints* 1.26 (1.16-1.36) <0.001
Parents global assessment of overal well-being [VAS 0-100 mm]* 1.02 (1.01-1.03) <0.001
Concomitant use of NSAIDs 1.89 (1.08-3.34) 0.027
Model performance:  
AUC 73.6%
Sensitivity 98.7%
Specificity 12.4%
Ped ACR70 at month 12
Disease duration >1 year 0.54 (0.39-0.77) 0.001
No. of tender joints* 0.92 (0.88-0.97) <0.001
No. of active joints* 1.10 (1.05-1.16) <0.001
Parent’s global assessment of child’s pain [VAS 0-100 mm]* 1.01 (1.00-1.01) 0.029
Presence of morning stiffness 1.58 (1.10-2.28) 0.014
Model performance:  
AUC 67.2%
Sensitivity 90.7%
Specificity 27.0%
  1. Specificity = probability for non-responders being correctly identified by the model, sensitivity = likewise defined probability for responders. AUC = area under the curve, OR = odd’s ratio, *per increment of 1 unit.