Table 5 Serious adverse events by current NSAID treatment
Patient ID | Current medication | Onset-resolution (daya) | Reported description | Outcome | Action taken (study medication) | Causality |
|---|---|---|---|---|---|---|
A | nsNSAID | 729–733 | Cellulitis | Resolved | No action taken | Other: spider bite |
B | nsNSAID | 478–481 | Benign fibrohistiocytic lesions with giant cells | Resolved | No action taken | Other: idiopathic hip pain |
C | nsNSAID | 303–307 | Appendicitis | Resolved | No action taken | Other: appendicitis |
D | nsNSAID | 27–N/A | Unintended pregnancy | Unknown | Permanently discontinued | Other: pregnancy |
E | nsNSAID | 33–39 | Meningitis | Resolved with sequelae | Permanently discontinued | Other illness: infection—probably viral |
F | nsNSAID | 160–167 | Fever and neutropenia | Resolved with sequelae | Stopped temporarily | Other illness: mycoplasma infection |
F | nsNSAID | 161–167 | Agranulocytosis | Resolved with sequelae | No action taken | Other illness: mycoplasma infection |
G | nsNSAID | 236–288 | Infection musculoskeletal septic arthritis | Resolved | Stopped temporarily | Other: unknown |
H | nsNSAID | 205–N/A | Onset of systemic JIA | Still present | Permanently discontinued | Other: systemic JIA |
I | nsNSAID | 93–149 | Right lower quadrant abdominal pain | Resolved | Stopped temporarily | Other: unknown possible subclinical appendicitis but pathology negative |
I | Celecoxib | 138–149 | Phlegmon | Resolved | Stopped temporarily | Other: postsurgical (appendectomy) complication |
I | Celecoxib | 659–N/A | Transformed migraine | Still present | Stopped temporarily | Other illness: likely related to past medical history of migraines |
J | Celecoxib | 82–246 | Exacerbation of disease | Resolved | No action taken | Disease under study |
J | Celecoxib | 82–132 | Fever | Resolved | No action taken | Disease under study |
K | Off NSAID | 69–N/A | Primary sclerosing cholangitis | Still present | Permanently discontinued | Other illness: primary sclerosing cholangitis |
G | Off NSAID | 452–N/A | Septic arthritis | Still present | No action taken | Other illness: septic arthritis of unknown etiology |
G | Off NSAID | 471–512 | Acute tubular necrosis | Resolved | Permanently discontinued | Other: vancomycin |
L | Off NSAID | 424–429 | Febrile neutropenia | Resolved | No action taken | Other illness: infection questionable Rocky Mountain spotted fever |