Skip to main content

Table 1 Laboratory values

From: High dose anakinra for treatment of severe neonatal Kawasaki disease: a case report

Hospital Day

CRP, mg/dl (normal <10)

ESR, mm/hr (normal <15)

Hb, g/dl (normal 12.5-19)

WBC × 103/mm3 (normal 6–18)

Neutrophil (%) (normal 19–45)

PLTs × 103/mm3 (normal 140–400)

AST, U/l (normal 15–60)

ALT, U/l (normal 10–40)

Triglyceride, mg/dl (normal <149)

Fibrinogen, mg/dl (range 220–450)

Ferritin, ng/ml (normal 50–200)

GGT, U/l (normal 8–80)

Other labs and important events related to clinical course:

1

  

9.6

14.3

57

229

      

Serum sodium 130 mEq/L Total bilirubin 3.5 mg/dL

3

133.4

40

6.9

12.12

59

32

25

18

   

138

Serum sodium 131 mEq/L Hypoalbuminemia of 1.8 g/dL (reference range: 3.4-5.4 g/dL) IVIG dose #1

4

  

10.1

16.8

 

121

24

19

82

 

801

 

IVIG dose #2/Transfusion

6

191.6

24

9.9

27.5

 

66

22

17

 

239

255

 

IVIG dose#3 Methylprednisolone 30 mg/kg × 3 days Flow cytometry

7

234.1

113

8.2

16.6

 

52

   

273

207

 

Anakinra started

(3 mg/kg BID) (increased to 3 mg/kg TID after 3 days)

8

122.9

64

7.8

21.5

 

133

16

14

  

213

 

Slight clinical improvement

9

65

37

12.7

22.6

 

156

  

165

   

Methylprednisolone (1 mg/kg BID) Marked clinical improvement Extubated day 9 Tranfusion

12

98.3

67

13.2

19.6

 

607

32

21

288

 

574

 

Echocardiogram: diffuse enlargement of the entire coronary artery system Infliximab 5 mg/kg ×1 Methylprednisolone increased (4 mg/kg TID)

16

1.6

25

11.3

12.9

 

963

27

28

201

239

700

108

Methylprednisolone decreased (2 mg/kg TID)

20

0.3

5

13

20.9

 

972

  

269

212

754

134

Methylprednisolone decreased (2 mg/kg Daily)

27

<0.2

8

11.3

16.7

 

427

  

293

 

406

58

Anakinra decreased (4 mg/kg BID) Methylprednisolone stopped Prednisolone started 1.5 mg/kg Daily (tapered over 10 days)

  1. CRP: C-reactive protein; ESR: erythrocyte sedimentation rate; Hb: hemoglobin; WBC: white blood count; PLTs: platelets; AST: aspartate aminotransferase; ALT: alanine aminotransferase; GGT: gamma-glutamyl transpeptidase; IVIG: intravenous immunoglobulin treatment.