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Table 3 Analyses of autoantibodies in 147 patients from the Nordic JIA database followed for eight years in association with age at disease onset, number of cumulative joints, remission and articular damage

From: Anti-type II collagen antibodies, anti-CCP, IgA RF and IgM RF are associated with joint damage, assessed eight years after onset of juvenile idiopathic arthritis (JIA)

  Total Age at onset (n = 147) Cumulative joints during the first eight years of disease (n = 147) Remission after 8 years (n = 147) Articular damage*** at eight year follow up (n = 147)
  n (%) Median (IQR) p* Median (IQR) p* Number of patients without remission/total number (%) p** Number of patients with damage/total number (%) p**
Total cohort 147 5.4 (2.8-9.9)   8 (3–15)   99/147 (67%)   18/147 (12)  
IgM RF positive 6 (4.1%) 10.5 (13.0-13.4) 0.002 8 (2–20) 0.79 3/6 (50%) 0.39 3/6 (50) 0.0068
IgA RF positive 6 (4.1%) 11.4 (7.6-13.2) 0.07 16 (4–18) 0.57 1/6 (17%) 0.66 4/6 (67) 0.0001
Anti-CCP positive 5 (3.4%) 11.0 (6.0-12.6) 0.15 18 (4–22) 0.89 1/5 (20%) 1.00 3/5 (60) 0.0007
Anti-collagen II positive 5 (3.4%) 4.8 (4.2-11.4) 0.54 13 (6–26) 0.29 2/5 (40%) 0.66 2/5 (40) 0.0274
Any conventional# antibody         5/11 0.0004
Any antibody¤         6/15 0.0004
  1. *Mann–Whitney U test, as compared with patients without the corresponding autoantibody.
  2. **Fisher’s Exact Test, as compared with patients without the corresponding autoantibody.
  3. ***Articular damage at eight-year follow-up according to JADI-A (score 0–72).
  4. #Positive for one or more antibodies: IgM RF, IgA RF and/or anti-CCP.
  5. ¤Positive for one or more antibodies: IgM RF, IgA RF, anti-CCP and/or anti-collagen II.