| |
Total
|
Age at onset (n = 147)
|
Cumulative joints during the first eight years of disease (n = 147)
|
Remission after 8 years (n = 147)
|
Articular damage*** at eight year follow up (n = 147)
|
|---|
| |
n (%)
|
Median (IQR)
|
p*
|
Median (IQR)
|
p*
|
Number of patients without remission/total number (%)
|
p**
|
Number of patients with damage/total number (%)
|
p**
|
|---|
|
Total cohort
|
147
|
5.4 (2.8-9.9)
| |
8 (3–15)
| |
99/147 (67%)
| |
18/147 (12)
| |
|
IgM RF positive
|
6 (4.1%)
|
10.5 (13.0-13.4)
|
0.002
|
8 (2–20)
|
0.79
|
3/6 (50%)
|
0.39
|
3/6 (50)
|
0.0068
|
|
IgA RF positive
|
6 (4.1%)
|
11.4 (7.6-13.2)
|
0.07
|
16 (4–18)
|
0.57
|
1/6 (17%)
|
0.66
|
4/6 (67)
|
0.0001
|
|
Anti-CCP positive
|
5 (3.4%)
|
11.0 (6.0-12.6)
|
0.15
|
18 (4–22)
|
0.89
|
1/5 (20%)
|
1.00
|
3/5 (60)
|
0.0007
|
|
Anti-collagen II positive
|
5 (3.4%)
|
4.8 (4.2-11.4)
|
0.54
|
13 (6–26)
|
0.29
|
2/5 (40%)
|
0.66
|
2/5 (40)
|
0.0274
|
|
Any conventional# antibody
| | | | | | | |
5/11
|
0.0004
|
|
Any antibody¤
| | | | | | | |
6/15
|
0.0004
|
- *Mann–Whitney U test, as compared with patients without the corresponding autoantibody.
- **Fisher’s Exact Test, as compared with patients without the corresponding autoantibody.
- ***Articular damage at eight-year follow-up according to JADI-A (score 0–72).
- #Positive for one or more antibodies: IgM RF, IgA RF and/or anti-CCP.
- ¤Positive for one or more antibodies: IgM RF, IgA RF, anti-CCP and/or anti-collagen II.
