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Table 2 Baseline bone biopsies findings in 12 patients with IJO

From: Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography

  Parameter Median Minimum Maximum Normal range (10–11)
Volume Trabecular separation (Tb.Sp) (μm) 432 367 610 299–587
Trabecular number (Tb.N) (#/mm) 1.83 1.42 2.14 1.3–2.7
Trabecular thickness (Tb.Th) (μm) 107 79 145 72–177
Bone volume (BV/TV) (%) 19.71 13.61 26.8 9.3–22.7
Mineralization Mineral apposition rate (MAR) (μm/day) 0.8 0.5 0.99 0.9–2.4
Mineralization lag time (MLT) (days) 18.13 4.59 105.12 4.1–71.7
Osteoid maturation time (OMT) (days) 8.68 4.11 15.57 1.9–10.4
Osteoid thickness (O.Th) (μm) 6.92 2.73 9.61 3–13.9
Osteoid volume (OV/BV) (%) 1.21 0.26 4.65 0.2–5.86
Osteoid surface (OS/BS) (%) 8.69 3.15 30.39 1.4–23.96
Turnover Bone formation rate (BFR/BS) (μm2/mm3/year) 12.81 1.95 78.91 10–73.4
Eroded surface (ES/BS) (%) 4.28 0 13.27 1.6–6.84