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Table 1 Main clinical characteristics of the 15 patients with IJO

From: Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography

  Sex Familial bone history Genetic or skin analysis Clinical score Age first referral (years) Age first symptom (years) Time between first symptom and diagnosis (years) Centile-size at diagnosis Main initial symptom Back pains Legs pains Chest Vertebral compression fracture Other symptoms
1 M 3 fractures mother, brother of pt2 Negative 2 15.4 6.0 9.4 90 fracture No No No No Increased urinary NTX
2 F Osteoporosis mother, sister of pt1 NP 1 13.5 5.0 8.5 45 back pain Yes No No No Transient hyperPTH
3 M No Negative 2 8.2 2.5 5.7 95 fracture No No No No No
4 M Osteoporosis grand-mother Negative 2 14.3 14.0 0.3 85 fracture Yes Yes No No Increased urinary NTX
5 F No Negative 1 5.9 5.5 0.4 50 fracture No No No No No
6 M Osteoporosis grand-mother NP 1 13.3 10.5 2.8 75 fracture No No No No No
7 F No Negative 1 7.8 7.6 0.2 90 osteopenia No No No No No
8 M Rheumatoidarthritis mother Negative 2 12.9 8.0 4.9 80 fracture Yes Yes No No Skin hyperpigmentation, Low 25-vitD
9 M Parathyroid adenoma father Negative 2 10.2 3.5 6.7 90 fracture No No No No No
10 M Twin brother (pt 11) with fractures Negative 2 13.9 5.0 8.9 98 fracture No No No No No
11 M Twin brother (pt 10) with fractures Negative 1 13.9 13.0 0.9 98 fracture No No No No No
12 M Osteoporosis grand-mother Negative 2 5.5 1.5 4.0 15 fracture No Yes No No No
13 M Scoliosis father NP 2 8.1 5.0 3.1 95 fracture Yes No Yes Yes No
14 M No NP 2 9.5 9.0 0.5 15 fracture Yes Yes Yes Yes Osteomyelitis radius and avascular necrosis, Transient hypercalciuria
15 F NA NA 2 10.0 NA NA NA fracture NA NA NA NA NA
  1. NA: non available data.
  2. NP: not performed.
  3. M/F: male/female.
  4. PTH: parathyroid hormone.