Table 2 Conditions associated with high IgG level in a pediatic cohort

Lupus/MCTD/SS (82)

Chronic/recurrent (88)

 Acute lymphoblastic leukemia

  Dicoid lupus

  Atopic dermatitis with superinfection

 Burkitt lymphoma

  Mixed connective tissue disorder

  Chronic sinusitis

 Castleman’s disease

  Systemic lupus erythematosus

  Chronic lung disease

 Chronic myelogenous leukemia

  Sjogren syndrome

  Cystic fibrosis

 Hodgkin lymphoma

Arthritis (60)

Suppurative (11)

 JMML

  Polyarticular JIA

  Abscess

 GVHD after HSCT

  Psoriatic arthritis

  Pyogenic pneumonia

 Neuroblastoma

  Systemic onset JIA

Streptococcus-associated (22)

  Spondyloarthritis

  Acute rheumatic fever

Immunodeficiency (15)

Vasculitis (12)

  Post-strep arthritis

 Autoimmune lymphoprolif. syndrome

  Polyarteritis nodosa

  Post-strep glomerulonephritis

 Autoimmune polyglandular syndrome

  Takayasu’s arteritis

  Streptococcal pneumonia

 Ataxia telangiectasia

  Granulomatosis with polyangiitis (GPA)

  Streptococcal sepsis

 Congenial neutropenia

  Eosinophilic GPA

Viral Immune Activation (19)

 Hyper IgE syndrome

  Gastrointestinal (39)

  CMV

 IgA deficiency

  Autoimmune hepatitis

  EBV

 NK cell dysfunction

  Crohn’s disease

  HIV

  Ulcerative colitis

Other (23)

Drug-associated (9)

  Primary sclerosing cholangitis

  Brucellosis

 Acute drug hypersensitivity reaction

Other Autoimmune (28)

  Endocarditis

 Drug-induced autoimmunity

  Acute demyelinating encephalomyelitis

  Lyme disease

  Autoimmune hemolytic anemia

  Osteomyelitis

Other (25)

  Anti-phospholipid syndrome

  Tuberculosis

 Cirrhosis

  Idiopathic thrombocytopenic purpura

  Urinary tract infection

 Hemoglobin SS

  Juvenile dermatomyositis

  Viral encephalitis

 IgA nephropathy

  Kawasaki disease

 Liver steatosis

  NOMID

 Lymphatic malformation

  Sweet syndrome

 Orthostatic proteinuria

  Undefined autoimmune condition

 Portal hypertension

 Spastic cerebral palsy trisomy 21