| |
Hinks et al. [[5]]
|
Kaalla et al. (Present)
|
Combined
|
|---|
|
Category
|
Size
|
MAF
|
OR (95% CI)
|
Size
|
MAF
|
OR (95% CI)
|
OR (95% CI)
|
p-value
|
|---|
|
Systemic
|
118
|
0.09
|
0.89 (0.55, 1.44)
|
50
|
0.11
|
1.05 (0.55, 2.01)
|
0.94 (0.64, 1.39)
|
0.7675
|
|
RF-Positive
|
35
|
0.17
|
1.79 (0.94, 3.43)
|
48
|
0.21
|
2.24 (1.33, 3.77)
|
2.05 (1.37, 3.77)
|
<0.0005
|
|
RF-Negative
|
135
|
0.2
|
2.12 (1.49, 3.02)
|
154
|
0.12
|
1.13 (0.77, 1.66)
|
1.56 (1.21, 2.02)
|
0.0007
|
|
ERA
|
48
|
0.14
|
1.36 (0.74, 2.51)
|
55
|
0.11
|
1.04 (0.56, 1.94)
|
1.19 (0.77, 1.84)
|
0.4431
|
|
Oligoarticular
|
276
|
0.15
|
1.56 (1.16, 2.10)
|
284
|
0.14
|
1.36 (1.01, 1.82)
|
1.45 (1.18, 1.79)
|
<0.0005
|
|
Controls
|
595
|
0.1
|
NA
|
733
|
0.11
|
NA
|
NA
|
NA
|
- PTPN22 allele frequency and odds ratios from Hinks et al. [5] and Kaalla et al. (Present) divided by five JIA categories. No covariates were included in the analyses. Pooled data significant at the α = 0.05 threshold level is bolded.
