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Table 5 Meta-Analysis results for PTPN22 C1858T subtypes: combining Hinks et al. [[5]] data with data from our cohort

From: Meta-analysis confirms association between TNFA- G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA

  Hinks et al. [[5]] Kaalla et al. (Present) Combined
Category Size MAF OR (95% CI) Size MAF OR (95% CI) OR (95% CI) p-value
Systemic 118 0.09 0.89 (0.55, 1.44) 50 0.11 1.05 (0.55, 2.01) 0.94 (0.64, 1.39) 0.7675
RF-Positive 35 0.17 1.79 (0.94, 3.43) 48 0.21 2.24 (1.33, 3.77) 2.05 (1.37, 3.77) <0.0005
RF-Negative 135 0.2 2.12 (1.49, 3.02) 154 0.12 1.13 (0.77, 1.66) 1.56 (1.21, 2.02) 0.0007
ERA 48 0.14 1.36 (0.74, 2.51) 55 0.11 1.04 (0.56, 1.94) 1.19 (0.77, 1.84) 0.4431
Oligoarticular 276 0.15 1.56 (1.16, 2.10) 284 0.14 1.36 (1.01, 1.82) 1.45 (1.18, 1.79) <0.0005
Controls 595 0.1 NA 733 0.11 NA NA NA
  1. PTPN22 allele frequency and odds ratios from Hinks et al. [5] and Kaalla et al. (Present) divided by five JIA categories. No covariates were included in the analyses. Pooled data significant at the α = 0.05 threshold level is bolded.