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Table 5 Meta-Analysis results for PTPN22 C1858T subtypes: combining Hinks et al. [[5]] data with data from our cohort

From: Meta-analysis confirms association between TNFA- G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA

 

Hinks et al. [[5]]

Kaalla et al. (Present)

Combined

Category

Size

MAF

OR (95% CI)

Size

MAF

OR (95% CI)

OR (95% CI)

p-value

Systemic

118

0.09

0.89 (0.55, 1.44)

50

0.11

1.05 (0.55, 2.01)

0.94 (0.64, 1.39)

0.7675

RF-Positive

35

0.17

1.79 (0.94, 3.43)

48

0.21

2.24 (1.33, 3.77)

2.05 (1.37, 3.77)

<0.0005

RF-Negative

135

0.2

2.12 (1.49, 3.02)

154

0.12

1.13 (0.77, 1.66)

1.56 (1.21, 2.02)

0.0007

ERA

48

0.14

1.36 (0.74, 2.51)

55

0.11

1.04 (0.56, 1.94)

1.19 (0.77, 1.84)

0.4431

Oligoarticular

276

0.15

1.56 (1.16, 2.10)

284

0.14

1.36 (1.01, 1.82)

1.45 (1.18, 1.79)

<0.0005

Controls

595

0.1

NA

733

0.11

NA

NA

NA

  1. PTPN22 allele frequency and odds ratios from Hinks et al. [5] and Kaalla et al. (Present) divided by five JIA categories. No covariates were included in the analyses. Pooled data significant at the α = 0.05 threshold level is bolded.
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Pediatric Rheumatology

ISSN: 1546-0096