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Table 4 Meta-analysis results for PTPN22, MIF and TNFA variants and JIA

From: Meta-analysis confirms association between TNFA- G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA

   Cases Controls    
Gene   # Cases MAF # Controls MAF OR (95% CI) p-value Data sources
PTPN22 C1858T All Studies 3261 0.14 4982 0.11 1.44 (1.31, 1.60) <0.0001 4-7, 18,19, 29
MIF G-173C Including Donn et al. [16] 1382 0.19 1544 0.17 1.26 (1.09, 1.45) 0.0356 9, 13, 16
Removing Donn et al. 856 0.19 1285 0.18 1.12 (0.96, 1.32) 0.1548  
TNFA G-238A Including Ozen et al. [22] 1399 0.07 1648 0.07 0.84 (0.68, 1.04) 0.1033 9, 11, 20, 22, 23
Removing Ozen et al. 1189 0.03 1455 0.04 0.69 (0.52, 0.91) 0.0086  
TNFA G-308A Including Ozen et al. [22] 1583 0.17 1952 0.16 1.01 (0.88, 1.15) 0.925 9, 11, 12, 20-23
Removing Ozen et al. 1373 0.15 1759 0.16 0.95 (0.83, 1.10) 0.5137