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Table 3 Studies included in meta-analyses

From: Meta-analysis confirms association between TNFA- G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA

      Cases Controls
Gene Author Ref number Country Publication year # Cases MAF # Controls MAF
PTPN22 C1858T Seldin et al. [7] Finland 2005 230 0.18 1400 0.15
Hinks et al. [5] UK 2005 661 0.15 595 0.10
Cinek et al. [18] Czech/Azeri 2007 130 0.21 400 0.10
Pazar et al. [19] Hungary 2008 150 0.09 200 0.08
Thompson et al. [4] USA 2010 809 0.14 531 0.09
Ellis [29] Australian 2013 324 0.10 568 0.07
Viken et al. [6] Norway 2005 320 0.16 555 0.12
Kaalla et al. Present USA   637 0.13 733 0.11
MIF G-173C Donn et al.* [[16]] UK 2002 526 0.19 259 0.11
Miterski et al. [9] Germany 2004 150 0.24 390 0.21
Berdeli et al. [13] Turkey 2006 67 0.13 153 0.10
Kaalla et al. Present USA   639 0.18 742 0.17
TNFA G-238A Ozen et al.* [[22]] Turkey 2002 51 0.22 93 0.27
Ozen et al.* [[22]] Czech 2002 159 0.23 100 0.17
Zeggini et al. [23] UK 2002 137 0.03 76 0.09
Miterski et al. [9] Germany 2004 130 0.02 375 0.03
Modesto et al. [20] Spain 2005 55 0.07 59 0.09
Schmeling et al. [11] Germany 2006 228 0.03 196 0.03
Kaalla et al. Present USA   639 0.04 749 0.06
TNFA G-308A Ozen et al.* [22] Turkey 2002 51 0.25 93 0.31
Ozen et al.* [22] Czech 2002 159 0.27 100 0.16
Zeggini et al. [23] UK 2002 138 0.24 75 0.13
Miterski et al. [9] Germany 2004 122 0.17 312 0.16
Modesto et al. [20] Spain 2005 55 0.13 59 0.12
Schubert et al. [12] Germany 2006 86 0.15 270 0.15
Schmeling et al. [11] Germany 2006 228 0.14 196 0.17
Mourao et al. [21] Portugal 2009 115 0.12 118 0.11
Kaalla et al. Present USA   629 0.14 729 0.17
  1. *Bolded studies were removed from analysis due to evidence for heterogeneity, using Cochran’s Q test (p < 0.10 threshold).