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Table 2 Results of case-control association of PTPN22, MIF and TNFA variants among JIA sub-phenotypes

From: Meta-analysis confirms association between TNFA- G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA

  PTPN22 MIF TNFA G-238A TNFA G-308A
Subtype # Cases OR (95% CI) # Cases OR (95% CI) # Cases OR (95% CI) # Cases OR (95% CI)
Systemic 50 1.06 (0.53, 1.91) 49 1.53 (0.93, 2.45) 50 1.69 (0.76, 3.36) 50 0.33 (0.13, 0.69) 4
RF-Positive 48 2.12 (1.24, 3.49) 1 47 1.06 (0.60, 1.75) 48 * 47 0.98 (0.54, 1.66)
RF-Negative 154 1.09 (0.74, 1.57) 158 0.86 (0.61, 1.19) 157 1.14 (0.67, 1.86) 156 0.85 (0.60, 1.18)
ERA 55 1.09 (0.55, 1.97) 56 1.23 (0.74, 1.98) 56 0.94 (0.35, 2.06) 56 0.40 (0.18, 0.78) 5
Oligoarticular 284 1.35 (1.01, 1.80) 2 283 1.06 (0.83, 1.36) 284 0.33 (0.16, 0.59) 3 276 0.96 (0.73, 1.25)
  1. 1 p = 0.0041; 2 p = 0.0400; 3 p = 0.0006; 4 p = 0.0089; 5 p = 0.0144; Statistically significant results are bolded. * Represents an analysis that was not conducted due to small cell size.