Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system

Table 4 Levels of soluble IL-2 receptor alpha (sCD25) and sCD163 in children with the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA) and children with pneumonia (Pn)

	Pn-nf	PFAPA-nf	PFAPA-f	Pn-f
	(n=10)	(n=20)	(n=14/13*)	(n=14/12*)
sCD25 (pg/ml)	1162.3	1883.4	2980.2	2297.6
sCD25 (pg/ml)	(820.4, 2110.3)	(970.4, 2458.5)	(1032.4, 3624.4)	(1799.2, 3381.3)
sCD163 (ng/ml)	568.8	665.8	695.4	505.3
	(408.5, 735.0)	(555.7, 844.4)	(528.0, 813.0)	(391.3, 837.1)

Results are given as median (quartiles).
Pn-nf: Children with pneumonia after complete remission.
PFAPA-nf: Children with PFAPA between febrile episodes.
PFAPA-f: Children with PFAPA during febrile episodes.
Pn-f: Children with pneumonia shortly after admission.
For sCD25 measurements the p-value was 0.013 for PFAPA-f versus PFAPA-nf, and the p-value was 0.022 for Pn-f versus Pn-nf.
No other significant differences were found for sCD25 or sCD163.
* sCD163 was measured in 13 children with PFAPA and in 12 children with pneumonia.

ISSN: 1546-0096