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Table 4 Levels of soluble IL-2 receptor alpha (sCD25) and sCD163 in children with the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA) and children with pneumonia (Pn)

From: Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system

  Pn-nf PFAPA-nf PFAPA-f Pn-f
  (n=10) (n=20) (n=14/13*) (n=14/12*)
sCD25 (pg/ml) 1162.3 1883.4 2980.2 2297.6
(820.4, 2110.3) (970.4, 2458.5) (1032.4, 3624.4) (1799.2, 3381.3)
sCD163 (ng/ml) 568.8 665.8 695.4 505.3
  (408.5, 735.0) (555.7, 844.4) (528.0, 813.0) (391.3, 837.1)
  1. Results are given as median (quartiles).
  2. Pn-nf: Children with pneumonia after complete remission.
  3. PFAPA-nf: Children with PFAPA between febrile episodes.
  4. PFAPA-f: Children with PFAPA during febrile episodes.
  5. Pn-f: Children with pneumonia shortly after admission.
  6. For sCD25 measurements the p-value was 0.013 for PFAPA-f versus PFAPA-nf, and the p-value was 0.022 for Pn-f versus Pn-nf.
  7. No other significant differences were found for sCD25 or sCD163.
  8. * sCD163 was measured in 13 children with PFAPA and in 12 children with pneumonia.