Table 1 Levels of cytokines in children with the periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis syndrome (PFAPA) and children with pneumonia (Pn)
Pn-nf | p-value | PFAPA-nf | p-value | PFAPA-f | p-value | Pn-f | |
|---|---|---|---|---|---|---|---|
Pn-nf | PFAPA-f | PFAPA-f | |||||
vs | vs | vs | |||||
PFAPA-nf | PFAPA-nf | Pn-f | |||||
(n=10) | (n=21) | (n=13) | (n=14) | (n=14) | |||
IL-1β | nd | 0.004 | 2.5 | ns | 2.6 | 0.002 | nd |
(LoD: 0.8) | (0.1, 5.4) | (0.9, 5.1) | |||||
CXCL10 | 731.9 | 0.000 | 1762.5 | .003 | 4787.2 | 0.002 | 1512.7 |
(LoD: 6.5) | (582.7, 1038.0) | (1305.6, 3401.0) | (2801.1, 7743.5) | (685.5, 3179.4) | |||
IL-6 | 15.4 | ns | 11.2 | .001 | 49.6 | 0.035 | 21.7 |
(LoD: 1.1) | (9.5, 23.7 | (4.8, 19.0) | (21.1, 103.8) | (18.3, 29.7) | |||
CCL4 | 70.5 | ns | 52.8 | .019 | 63.0 | ns | 59.4 |
(LoD: 1.1) | (52.9, 83.6) | (30.3, 77.2) | (47.5, 93.4) | (44.7, 75.0) | |||
IL-17 | 41.6 | ns | 17.4 | ns | 7.4 | 0.002 | 64.5 |
(LoD: 0.2) | (25.4, 135.7) | (0.7, 54.6) | (0.7, 29.5) | (26.6, 81.2) | |||
CCL5 | 6878.3 | 0.017 | 3197.5 | ns | 3007.8 | 0.016 | 4856.7 |
(LoD: 1.2) | (4066.2, 7154.3) | (2200.8, 4694.1) | (1864.5, 4019.3) | (3028.0, 6916.8) | |||
IL-1ra | 234.0 | ns | 129.3 | ns | 121.5 | 0.002 | 249.3 |
(LoD: 1.4) | (116.4, 368.1) | (69.5, 196.8) | (95.7, 170.8) | (176.7, 328.9) | |||
IL-2 | 17.6 | 0.010 | nd | ns | nd | 0.000 | 17.6 |
(LoD: 1.1) | (7.3, 29.9) | (9.2, 21.7) | |||||
IL-9 | 24.4 | ns | 4.0 | ns | 6.0 | 0.011 | 29.7 |
(LoD: 0.7) | (11.6, 77.5) | (0.6, 30.8) | (0.5, 17.7) | (15.3, 41.3) | |||
CCL11 | 65.0 | ns | 20.8 | ns | nd | 0.007 | 59.3 |
(LoD: 14.6) | (10.4, 133.1) | (0.3, 71.6) | (14.7, 115.1) | ||||
FGF-2 | 35.9 | ns | 24.0 | ns | 26.4 | 0.044 | 44.7 |
(LoD: 6.8) | (24.5, 63.2) | (4.8, 47.7) | (14.1, 40.6) | (27.4, 55.7) | |||
G-CSF | 74.0 | ns | 92.0 | ns | 126.9 | 0.016 | 94.0 |
(LoD: 1.1) | (54.8, 103.4) | (61.6, 111.9) | (95.9, 169.0) | (55.6, 106.9) | |||
CCL2 | 38.0 | ns | 36.1 | ns | 38.0 | 0.039 | 27.6 |
(LoD: 6.8) | (34.5, 41.9) | (26.2, 42.1) | (28.4, 54.5) | (19.2, 32.9) | |||
CCL3 | 15.5 | ns | 3.0 | ns | 4.2 | 0.004 | 16.9 |
(LoD: 2.4) | (8.2, 21.5) | (0.2, 14.8) | (0.4, 7.0) | (13.6, 18.9) | |||
PDGF-BB | 1440.5 | 0.025 | 532.4 | ns | 406.0 | 0.004 | 1284.0 |
(LoD: 1.0) | (529.7, 1942.0) | (301.5, 910.1) | (263.2, 1093.6) | (1056.0, 2813.3) | |||
CXCL8 (IL-8) | 19.1 | ns | 20.1 | ns | 19.0 | ns | 24.3 |
(LoD: 0.5) | (12.7, 32.3) | (14.0, 29.9) | (15.6, 23.4) | (18.5, 29.1) | |||
INF-γ | 198.9 | ns | 279.4 | ns | 323.5 | ns | 226.6 |
(LoD: 19.3) | (125.3, 336.9) | (208.3, 418.9) | (235.3, 437.4) | (166.7, 306.3) | |||
IL-4 | 5.7 | ns | 7.0 | ns | 6.8 | ns | 6.8 |
(LoD: 0.5) | (3.1, 8.2) | (4.9, 9.8) | (4.9, 9.4) | (4.4, 8.2) | |||
IL-5 | 6.3 | ns | 5.7 | ns | 5.8 | ns | 12.0 |
(LoD: 0.8) | (1.8, 21.2) | (3.1, 9.4) | (4.5, 9.3) | (1.8, 18.3) | |||
IL-7 | 19.9 | ns | 25.9 | ns | 25.4 | ns | 19.5 |
(LoD: 0.5) | (11.5, 26.3) | (19.1, 31.1) | (19.4, 29.6) | (12.5, 26.3) | |||
IL-10 | 13.1 | ns | 6.5 | ns | 8.1 | ns | 8.3 |
(LoD: 0.9) | (1.6, 24.9) | (3.2, 13.7) | (4.3, 11.1) | (1.2, 16.8) | |||
IL-12p70 | 46.1 | ns | 25.8 | ns | 24.5 | ns | 40.4 |
(LoD: 0.5) | (18.5, 89.5) | (12.2, 40.8) | (18.1, 33.4) | (14.2, 72.2) | |||
IL-13 | 16.9 | ns | 10.1 | ns | 10.4 | ns | 13.3 |
(LoD: 2.1) | (8.3, 36.1) | (6.4, 17.5) | (7.6, 14.0) | (7.2, 21.9) | |||
IL-15 | nd | ns | nd | ns | nd | ns | nd |
(LoD: 4.2) | |||||||
GM-CSF | nd | ns | nd | ns | nd | ns | nd |
(LoD: 4.5) | |||||||
TNF-α | 66.2 | ns | 67.1 | ns | 68.1 | ns | 82.5 |
(LoD: 3.0) | (40.6, 126.8) | (42.9, 101.6) | (56.3, 113.1) | (55.9, 116.2) | |||
VEGF | 43.2 | ns | 22.3 | ns | 30.6 | ns | 38.3 |
(LoD: 0.5) | (24.4, 70.0) | (9.2, 47.1) | (9.1, 43.4) | (21.7, 87.3) |