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Table 1 SNPs significantly associated with JIA (p<0.05)

From: Autoinflammatory gene polymorphisms and susceptibility to UK juvenile idiopathic arthritis

SNP CHR Position Gene Major allele (allele 1) Minor allele (allele 2) MAF Case MAF Control pHWE Control Case genotype frequencies Control genotype frequencies p-value Odds ratio 95% CI
1/1 1/2 2/2 1/1 1/2 2/2
(%) (%) (%) (%) (%) (%)
rs2071374 2 113537352 IL1A A C 0.30 0.27 0.67 453 392 85 2751 2067 376 0.006 1.16 1.04-1.30
(48.7) (42.2) (9.1) (53.0) (39.8) (7.2)
rs2228576 12 6457062 TNFRSF1A G A 0.33 0.36 0.43 414 419 94 2136 2349 678 0.009 0.87 0.78-0.97
(44.7) (45.2) (10.1) (41.4) (45.5) (13.1)
rs11836136 12 110006512 MVK A G 0.29 0.26 1.00 460 380 74 2857 1992 347 0.006 1.17 1.04-1.30
(50.3) (41.6) (8.1) (55.0) (38.3) (6.7)
rs7957619 12 110013879 MVK G A 0.14 0.11 0.33 699 210 21 4099 1027 73 0.005 1.231.07-1.43
(75.2) (22.6) (2.3) (78.8) (19.8) (1.4)
  1. CHR=chromosome, MAF=minor allele frequency, CI=confidence interval, pHWE= p-value for departure from Hardy-Weinburg equilibrium.