Autoinflammatory gene polymorphisms and susceptibility to UK juvenile idiopathic arthritis

Table 1 SNPs significantly associated with JIA (p<0.05)

SNP	CHR	Position	Gene	Major allele (allele 1)	Minor allele (allele 2)	MAF Case	MAF Control	pHWE Control	Case genotype frequencies			Control genotype frequencies			p-value	Odds ratio 95% CI
									1/1	1/2	2/2	1/1	1/2	2/2
									(%)	(%)	(%)	(%)	(%)	(%)
rs2071374	2	113537352	IL1A	A	C	0.30	0.27	0.67	453	392	85	2751	2067	376	0.006	1.16 1.04-1.30
rs2071374	2	113537352	IL1A	A	C	0.30	0.27	0.67	(48.7)	(42.2)	(9.1)	(53.0)	(39.8)	(7.2)	0.006	1.16 1.04-1.30
rs2228576	12	6457062	TNFRSF1A	G	A	0.33	0.36	0.43	414	419	94	2136	2349	678	0.009	0.87 0.78-0.97
rs2228576	12	6457062	TNFRSF1A	G	A	0.33	0.36	0.43	(44.7)	(45.2)	(10.1)	(41.4)	(45.5)	(13.1)	0.009	0.87 0.78-0.97
rs11836136	12	110006512	MVK	A	G	0.29	0.26	1.00	460	380	74	2857	1992	347	0.006	1.17 1.04-1.30
rs11836136	12	110006512	MVK	A	G	0.29	0.26	1.00	(50.3)	(41.6)	(8.1)	(55.0)	(38.3)	(6.7)	0.006	1.17 1.04-1.30
rs7957619	12	110013879	MVK	G	A	0.14	0.11	0.33	699	210	21	4099	1027	73	0.005	1.231.07-1.43
rs7957619	12	110013879	MVK	G	A	0.14	0.11	0.33	(75.2)	(22.6)	(2.3)	(78.8)	(19.8)	(1.4)	0.005	1.231.07-1.43

CHR=chromosome, MAF=minor allele frequency, CI=confidence interval, pHWE= p-value for departure from Hardy-Weinburg equilibrium.

ISSN: 1546-0096