Best test p§ | Allelic | Evidence for replication?‡ | ||||||
---|---|---|---|---|---|---|---|---|
Gene | SNP | Minor allele | Case MAF | Control MAF | P | OR (95% CI) | ||
ADAD1-IL2-IL21 | rs17388568[6] | A | 0.25 | 0.24 | 0.29 R | 0.55 | 1.07 (0.85, 1.36) | N |
rs13143866[6] | A | 0.28 | 0.26 | 0.28 D | 0.31 | 1.12 (0.90, 1.40) | N | |
T | 0.13 | 0.12 | 0.42 R | 0.46 | 1.12 (0.83, 1.49) | N | ||
AFF3 | rs1160542[5] | G | 0.49 | 0.46 | 0.16 R | 0.25 | 1.12 (0.92, 1.36) | P |
ANGPT1 | rs1010824[6] | T | 0.17 | 0.16 | 0.71 D | 0.82 | 1.03 (0.79, 1.34) | N |
ATXN2 | rs653178[7] | G | 0.55 | 0.46 | 0.00023 A | 0.00023 | 1.44 (1.19, 1.76) | Y |
BACH2 | rs11755527[7] | G | 0.44 | 0.46 | 0.34 D | 0.41 | 0.92 (0.76, 1.12) | N |
C12orf30 | G | 0.50 | 0.41 | 0.00044 T | 0.0005 | 1.42 (1.16, 1.72) | Y | |
C3orf1 | rs4688011[9] | A | 0.24 | 0.19 | 0.016 D | 0.02 | 1.32 (1.04, 1.68) | Y |
CD14 | rs2569190[11] | A | 0.48 | 0.50 | 0.24 R | 0.43 | 0.92 (0.76, 1.12) | N |
CD226 | rs763361[5] | T | 0.52 | 0.48 | 0.059 A | 0.059 | 1.21 (0.99, 1.47) | P |
CLEC16A | rs6498169[12] | G | 0.37 | 0.35 | 0.30 A | 0.3 | 1.11 (0.91, 1.36) | N |
COG6 | rs7993214[6] | T | 0.30 | 0.29 | 0.41 T | 0.41 | 1.09 (0.88, 1.36) | N |
CTLA4 | rs3087243[5] | A | 0.46 | 0.46 | 0.80 R | 0.97 | 0.997 (0.82, 1.21) | N |
DCN1* | rs939898[22] | G | 0.21 | 0.18 | 0.057 D | 0.11 | 1.22 (0.95, 1.56) | N |
ERAP1† | rs30187[13] | T | 0.39 | 0.37 | 0.36 D | 0.46 | 1.08 (0.88, 1.32) | N |
FHIT* | rs9311745[22] | C | 0.07 | 0.08 | 0.86 A | 0.86 | 0.97 (0.66, 1.41) | N |
HUNK* | rs2833547[22] | T | 0.25 | 0.26 | 0.46 D | 0.66 | 0.95 (0.76, 1.19) | N |
IL15 | rs13139573[9] | T | 0.47 | 0.43 | 0.0016 G | 0.13 | 1.16 (0.96, 1.41) | ? |
IL23R | rs11209026[13] | A | 0.07 | 0.05 | 0.22 T | 0.23 | 1.29 (0.85, 1.94) | N |
rs11465804[6] | G | 0.06 | 0.05 | 0.44 T | 0.45 | 1.18 (0.77, 1.80 | N | |
IL2RA | rs12251307[6] | T | 0.11 | 0.12 | 0.34 A | 0.34 | 0.86 (0.63, 1.17) | N |
rs706778[2] | A | 0.45 | 0.43 | 0.26 T | 0.26 | 1.12 (0.92, 1.36) | N | |
G | 0.21 | 0.22 | 0.21 R | 0.63 | 0.94 (0.74, 1.20) | N | ||
IL7R | rs6897932[5] | T | 0.25 | 0.23 | 0.17 D | 0.19 | 1.16 (0.93, 1.46) | N |
JMJD1C-REEP3 | rs6479891[9] | T | 0.17 | 0.18 | 0.44 D | 0.64 | 0.94 (0.73, 1.21) | N |
rs12411988[9] | C | 0.16 | 0.17 | 0.47 R | 0.74 | 0.96 (0.73, 1.24) | N | |
KIF5A | rs1678542[15] | C | 0.36 | 0.39 | 0.22 A | 0.22 | 0.88 (0.72, 1.08) | N |
LPP | rs1464510[7] | T | 0.46 | 0.46 | 0.81 R | 0.93 | 1.01 (0.83, 1.23) | N |
MBL2 | rs1800451[16] | A | 0.03 | 0.02 | 0.059 T | 0.061 | 1.88 (0.96, 3.67) | P |
MEFV | rs224204[17] | T | 0.49 | 0.47 | 0.36 D | 0.38 | 1.09 (0.90, 1.33) | N |
NLRP30 | rs3806265[17] | C | 0.34 | 0.35 | 0.46 D | 0.54 | 0.94 (0.76. 1.15) | N |
NOD2 | rs1861759[17] | C | 0.39 | 0.37 | 0.26 D | 0.64 | 1.05 (0.86, 1.28) | N |
NRBF2-EGR2 | rs10995450[9] | T | 0.24 | 0.24 | 0.96 R | 0.98 | 0.998 (0.79, 1.25) | N |
PRKCQ | rs4750316[15] | C | 0.17 | 0.18 | 0.33 R | 0.42 | 0.90 (0.70, 1.17) | N |
PSTPIP10 | rs4078354[17] | T | 0.33 | 0.36 | 0.13 A | 0.85 (0.69, 1.05) | P | |
PTPN2 | rs1893217[6] | C | 0.20 | 0.18 | 0.50 A | 0.5 | 1.09 (0.85, 1.40) | N |
G | 0.19 | 0.18 | 0.43 D | 0.49 | 1.09 (0.85, 1.40) | N | ||
rs2542151[6] | G | 0.20 | 0.18 | 0.49 D | 0.53 | 1.08 (0.85, 1.39) | N | |
PTPN22 | A | 0.10 | 0.07 | 0.006 A | 0.006 | 1.62 (1.15, 2.30) | Y | |
RANTES (CCL5) | rs2107538[19] | T | 0.21 | 0.18 | 0.039 D | 0.097 | 1.23 (0.96, 1.58) | P∞ |
rs2280788[19] | G | 0.02 | 0.02 | 0.30 T | 0.31 | 1.45 (0.71, 2.96) | N | |
SLITRK5* | rs1074044[22] | C | 0.44 | 0.44 | 0.81 D | 0.9 | 1.01 (0.83, 1.23) | N |
STAT4 | rs8179673[15] | C | 0.29 | 0.24 | 0.012 D | 0.024 | 1.29 (1.03, 1.61) | Y |
rs3821236[6] | A | 0.25 | 0.21 | 0.013 D | 0.038 | 1.28 (1.01, 1.61) | Y | |
T | 0.29 | 0.24 | 0.0091 D | 0.025 | 1.29 (1.03, 1.61) | Y | ||
TNFAIP3 | A | 0.22 | 0.20 | 0.29 A | 0.29 | 1.14 (0.90, 1.44) | N | |
rs13207033[15] | A | 0.26 | 0.29 | 0.26 D | 0.29 | 0.89 (0.71, 1.11) | N | |
TRAF1-C5 | rs2900180[15] | T | 0.37 | 0.32 | 0.014 R | 0.046 | 1.23 (1.00, 1.51) | Y |
rs3761847[21] | A | 0.42 | 0.40 | 0.32 A | 0.32 | 1.11 (0.90, 1.36) | N | |
VTCN1 | rs12046117[22] | T | 0.17 | 0.15 | 0.33 A | 0.33 | 1.14 (0.87, 1.49) | N |