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Table 2

From: Developing juvenile localized scleroderma (jLS) consensus treatment regimens for comparative effectiveness studies

  Regimen
  MTX alone MTX + CS MTX + IV CS
MTX weekly dose 1 mg/kg SQ (max 25 mg) 1 mg.kg SQ (max 25 mg) 1 mg.kg SQ (max 25 mg)
Initial CS dose, duration None 2 mg/kg/day (max 60 mg) divided bid 30 mg/kg/dpse (max 1 gm)
   Duration: at least 2 weeks Either: 3 consecutive daily doses per month
    OR 1 dose per week
    Duration: 3 months
CS taper targets None Down to: None
   1 mg/kg/d (max 30 mg) by end of 2 months  
   0.5 mg/kg/d (max 15 mg) by end of 4 months  
   0.25 mg/kg/d (max 7.5 mg) by end of 6 months  
   Off CS by end of 48 weeks