Table 2

MTX weekly dose

1 mg/kg SQ (max 25 mg)

1 mg.kg SQ (max 25 mg)

1 mg.kg SQ (max 25 mg)

Initial CS dose, duration

None

2 mg/kg/day (max 60 mg) divided bid

30 mg/kg/dpse (max 1 gm)

Duration: at least 2 weeks

Either: 3 consecutive daily doses per month

OR 1 dose per week

Duration: 3 months

CS taper targets

None

Down to:

None

1 mg/kg/d (max 30 mg) by end of 2 months

0.5 mg/kg/d (max 15 mg) by end of 4 months

0.25 mg/kg/d (max 7.5 mg) by end of 6 months

Off CS by end of 48 weeks