Table 2
| Regimen | |||
|---|---|---|---|
| MTX alone | MTX + CS | MTX + IV CS | |
| MTX weekly dose | 1 mg/kg SQ (max 25 mg) | 1 mg.kg SQ (max 25 mg) | 1 mg.kg SQ (max 25 mg) |
| Initial CS dose, duration | None | 2 mg/kg/day (max 60 mg) divided bid | 30 mg/kg/dpse (max 1 gm) |
| Duration: at least 2 weeks | Either: 3 consecutive daily doses per month | ||
| OR 1 dose per week | |||
| Duration: 3 months | |||
| CS taper targets | None | Down to: | None |
| 1 mg/kg/d (max 30 mg) by end of 2 months | |||
| 0.5 mg/kg/d (max 15 mg) by end of 4 months | |||
| 0.25 mg/kg/d (max 7.5 mg) by end of 6 months | |||
| Off CS by end of 48 weeks | |||