Criteria (5 or more of the following) | |
---|---|
Fever (last 4/7 days) | Hemophagocytosis in tissue |
Splenomegaly | TG ≥265 mg/dl |
Bi-cytopenia (affecting ≥ 2 of 3 cell lineages) Platelets < 100,000/ml Neutrophils <1000/ml, Hgb < 9 g/dl | Ferritin ≥500 mcg/L |
Low NK (natural killer cells) activity | Elevated CD25 (sIL-2R) ≥ 2,400 U/ml |
Fibrinogen ≤ 1.5 g/L |