Prolidase deficiency associated with systemic lupus erythematosus (SLE): single site experience and literature review

Table 1 Clinical and laboratory findings in SLE associated with prolidase deficiency

Patient no (Reference)	1 Shrinath (1997³)	2 Shrinath (1997³)	3 Klar (2009)	4 Klar (2009)	5 Rocco (2007*⁴)	6 Bisonnette (1993⁹)	7 Marotte (2010)¹	8 Falik-Zaccai (2010¹⁰)	9 Falik-Zaccai (2010¹⁰)	10 Present report
Consanguinity	+	+	+	+	?	?	unknown	+	+	+
Ethnicity	Pakistan	Pakistan	Arab Moslem	Arab Moslem	?	?	Portugal	Druze	Arab Moslem	Druze
Sex	M	F	F	M	M	F	M	F	F	M
Age of PD/SLE diagnosis	9m/8y	6m/3y	/8y	/12y	?	/16y	/25y		5/8	2y/2.5
Skin involvement	+	+	+	+	+	+	+	+	+	+
Maculo-papular rash	+	+	+	-	+	+	-	+	+	+
Vasculitis	+	-	-	-	+	-	Necrotic lesion	-	-	+
Leg ulcers	-	-	+	+	+	+	+	-	-	-
Splenomegaly	+	-	+	+	-	-	+	+	+	+
Splenectomy	-	-	-	-		-		+	-	-
CNS involvement	-	-	-	-	-	-	-	_	+	_
seizure									+
Renal disease	+	-	-	-	-	+	+	-	+	+
Kidney biopsy	-	-	-			Class III	+		Class IV Kidney transplantation	Class IV
Renal failure	-		-			-				-
Hematological Disease	+	+	+					+	-	+
Anemia/Leukopenia/thrombopenia	+	+	+					+	-	+
Recurrent infections	+	+	+	+	-	+		+	+	-
Pulmonary disease	+	+	+	+		-	+	+	+	-
ANA	+	+	+	-	+	+		+	+	+
Positive ENA	+	+	+	+	+	+	1/640	+	+	+
Anti DNA	+	+	+	+	+	+	-	+	+	+
Hypocomplementemia	+	-	-	+	+	+	+	+	+	+
Fulfilled Criteria of SLE	+	+	-	-	-	+	"Rhupus"²syndrome	+	+	+

ISSN: 1546-0096