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Table 2 Variables associated with the likelihood of developing ankylosing spondylitis after a mean of 12.2 years (10 to14) ref. [[60]]* and radiographic sacroiliitis after a mean of 14.9 years (11.7 to 25.1) ref. [[61]]

From: The assessment of the spondyloarthritis international society concept and criteria for the classification of axial spondyloarthritis and peripheral spondyloarthritis: A critical appraisal for the pediatric rheumatologist

 

Univariate analysis

Multlivariate analysis

OR

95%CI

p

OR

95%CI

p

Male

5.37

2.00-14.44

0.001

2.92

0.93-9.12

0.066

Onset age ≥8 years

21.12

2.809-159.48

0.003

9.21

1.11-76.40

0.039

Family history of AS

9.94

3.67-26.92

0.000

ND

  

HLA-B27

10.35

3.63-29.54

0.000

5.29

1.63-17.17

0.005

DRB1*04

4.38

1.72-11.13

0.002

1.55

0.50-4.89

0.448

Enthesitis at 6 months*

42.5

6.3-1766.6

0.000

ND

  

Enthesitis at 6 months

8.06

1.31-46.96

0.020

ND

  

Enthesitis at 12 months*

22.1

6.1-118.1

0.000

ND

  

Tarsitis at 6 months*

39.2

5.7-1641.1

0.000

ND

  

Tarsitis at 12 months*

8.0

3.1-22.1

0.000

ND

  

Hip arthritis at 6 months

6.34

2.30-17.46

0.000

4.98

1.32-18.70

0.017

IBP/SIJ* pain at 6 months

10.5

1.1-505.5

0.01

ND

  

IBP at 6 months

16.22

2.16-121.9

0.007

ND

  

Psoriasis

7.23

1.72-30.49

0.007

ND

  
  1. *35 patients with juvenile-onset ankylosing spondylitis compared with 75 patients with systemic, polyarticular, and pauciarthritis type 1 juvenile rheumatoid arthritis. OR and 95%CI were recalculated and differ from those reported in the original publication ref. [60]. In this sample, no multivariate analysis was performed.
  2. 314 patients with juvenile idiopathic arthritis ref. [61].
  3. In a 15-year extended follow-up of 55 patients with enthesitis related arthritis years, DRB1*04 (OR 4.13, 95%CI 1.26-13.46, p = 0.19; univariate analysis), hip arthritis at 6 months (OR 46.73, 95%CI 1.16-39.34; multivariate analysis), and high sedimentation rate for at least 6 month (OR 4.09, 95%CI 1.05-15.91; multivariate analysis) were associated with radiographic sacroiliitis ref. [63].
  4. OR = odds ratio. 95%CI = 95% confidence intervals. AS = ankylosing spondylitis. ND = not determined. IBP = inflammatory back pain. SIJ = sacroiliac joint pain.