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Table 1 Initial clinical manifestations and laboratory characteristics of pediatric SLE patients of different pubescent age groups

From: Differential manifestations of prepubescent, pubescent and postpubescent pediatric patients with systemic lupus erythematosus: A retrospective study of 96 Chinese children and adolescents

Characteristics Group A(n = 8) Group B (n = 49) Group C (n = 39) Significance
Mean onset age: years (range) 6.8 (4.7-7.9) 11(8.8-12.9) 14.6(13–17.9)  
Gender (F:M) 7:1 2.5:1 4.6:1 ns
Positive family history (%) 1(12.5) 7 (14.3) 7 (18) ns
Mean disease duration before diagnosis: months (range) 21.3 (0.8-90) 9.2 (0.1-96) 4.4 (0.3-24) ns
Organ involvement (%)     
Mucocutaneous 6 (75) 35 (71.4) 29 (74.4) ns
 Malar rash 5 (62.5) 26 (53.1) 19 (48.7) ns
 Discoid rash 1 (12.5) 3 (6.1) 2 (5.1) ns
 Oral ulcer 4 (50) 19 (38.8) 12 (30.8) ns
 Photosensitivity 2 (25) 6 (12.2) 3 (7.7) ns
 Alopecia 0 (0) 7 (14.3) 7 (18) ns
Musculoskeletal 5 (62.5) 26 (53.1) 21 (53.9) ns
 Myalgia 1 (12.5) 3 (6.1) 4 (10.3) ns
 Arthritis 4 (50) 24 (49) 19 (48.7) ns
Reticuloendothelial system 3 (37.5) 6 (12.2) 6 (15.4) ns
Lymphadenopathy 2 (25) 4 (8.2) 3 (7.7) ns
Splenomegaly 1 (12.5) 0 (0) 2 (5.1) ns
Hepatic 1 (12.5) 2 (4.1) 1 (2.6) ns
Gastrointestinal 1 (12.5) 2 (4.1) 3 (7.7) ns
Renal 1 (12.5) 24 (49) 23 (59) p = 0.01
 WHO class I 0/0 (0) 0/12 (0) 0/8 (0) ns
 WHO class II 0/0 (0) 1/12 (8.3) 2/8 (25) ns
 WHO class III 0/0 (0) 4/12 (33.3) 0/8 (0) ns
 WHO class IV 0/0 (0) 9/12 (75) 5/8 (62.5) ns
 WHO class V 0/0 (0) 4/12 (33.3) 1/8 (12.5) ns
 WHO class VI 0/0 (0) 0/12 (0) 1/8 (12.5) ns
Central nervous system 0 (0) 3 (6.1) 1 (2.6) ns
Serositis 0 (0) 5 (10.2) 9 (23.1) ns
Pleural effusion 0 (0) 4 (8,2) 6 (15.4) ns
Pericardial effusion 0 (0) 2 (4.1) 5 (12.8) ns
Ascites/Peritonitis 0 (0) 2 (4.1) 4 (10.3) ns
Hematologic 6 (75) 38 (77.6) 34 (87.2) ns
 Anemia 6 (75) 34 (69.4) 30 (76.9) ns
 Leukopenia 0 (0) 17 (34.7) 13 (33.3) ns
 Lymphopenia 1 (12.5) 18 (36.7) 25 (64.1) p = 0.005
 Thrombocytopenia 1 (12.5) 9 (18.4) 12 (30.8) ns
 Laboratory (%)     
Low C3 3 (37.5) 41 (83.7) 34 (87.2) p = 0.004
Low C4 3 (37.5) 42 (85.7) 34 (87.2) p = 0.03
Autoantibodies positive :number (%)     
ANA 8 (100) 46 (93.9) 36 (92.3) ns
Anti-dsDNA antibody 5 (62.5) 44 (89.8) 30 (76.9) ns
aCL 0/2 (0) 4/12 (33.3) 3/18 (16.7) ns
LAC 0/2 (0) 1/13 (7.7) 1/18 (5.6) ns
Anti-ENA     
Anti-RNP 3/6 (50) 10/30 (33.3) 4/29 (13.8) ns
Anti-Jo-1 1/6 (16.7) 0/30 (0) 0/29 (0) p = 0.012
Anti-Scl-70 0/6 (0) 3/30 (10) 1/29 (3.4) ns
Anti-Ro 4/6 (66.6) 10/30 (33.3) 11/29 (37.9) ns
Anti-La 2/6 (33.3) 4/30 (13.3) 3/29(10.3) ns
Anti-Sm 1/6 (16.7) 10/30 (33.3) 0/29 (0) p = 0.009