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Table 1 Initial clinical manifestations and laboratory characteristics of pediatric SLE patients of different pubescent age groups

From: Differential manifestations of prepubescent, pubescent and postpubescent pediatric patients with systemic lupus erythematosus: A retrospective study of 96 Chinese children and adolescents

Characteristics

Group A(n = 8)

Group B (n = 49)

Group C (n = 39)

Significance

Mean onset age: years (range)

6.8 (4.7-7.9)

11(8.8-12.9)

14.6(13–17.9)

 

Gender (F:M)

7:1

2.5:1

4.6:1

ns

Positive family history (%)

1(12.5)

7 (14.3)

7 (18)

ns

Mean disease duration before diagnosis: months (range)

21.3 (0.8-90)

9.2 (0.1-96)

4.4 (0.3-24)

ns

Organ involvement (%)

    

Mucocutaneous

6 (75)

35 (71.4)

29 (74.4)

ns

 Malar rash

5 (62.5)

26 (53.1)

19 (48.7)

ns

 Discoid rash

1 (12.5)

3 (6.1)

2 (5.1)

ns

 Oral ulcer

4 (50)

19 (38.8)

12 (30.8)

ns

 Photosensitivity

2 (25)

6 (12.2)

3 (7.7)

ns

 Alopecia

0 (0)

7 (14.3)

7 (18)

ns

Musculoskeletal

5 (62.5)

26 (53.1)

21 (53.9)

ns

 Myalgia

1 (12.5)

3 (6.1)

4 (10.3)

ns

 Arthritis

4 (50)

24 (49)

19 (48.7)

ns

Reticuloendothelial system

3 (37.5)

6 (12.2)

6 (15.4)

ns

Lymphadenopathy

2 (25)

4 (8.2)

3 (7.7)

ns

Splenomegaly

1 (12.5)

0 (0)

2 (5.1)

ns

Hepatic

1 (12.5)

2 (4.1)

1 (2.6)

ns

Gastrointestinal

1 (12.5)

2 (4.1)

3 (7.7)

ns

Renal

1 (12.5)

24 (49)

23 (59)

p = 0.01

 WHO class I

0/0 (0)

0/12 (0)

0/8 (0)

ns

 WHO class II

0/0 (0)

1/12 (8.3)

2/8 (25)

ns

 WHO class III

0/0 (0)

4/12 (33.3)

0/8 (0)

ns

 WHO class IV

0/0 (0)

9/12 (75)

5/8 (62.5)

ns

 WHO class V

0/0 (0)

4/12 (33.3)

1/8 (12.5)

ns

 WHO class VI

0/0 (0)

0/12 (0)

1/8 (12.5)

ns

Central nervous system

0 (0)

3 (6.1)

1 (2.6)

ns

Serositis

0 (0)

5 (10.2)

9 (23.1)

ns

Pleural effusion

0 (0)

4 (8,2)

6 (15.4)

ns

Pericardial effusion

0 (0)

2 (4.1)

5 (12.8)

ns

Ascites/Peritonitis

0 (0)

2 (4.1)

4 (10.3)

ns

Hematologic

6 (75)

38 (77.6)

34 (87.2)

ns

 Anemia

6 (75)

34 (69.4)

30 (76.9)

ns

 Leukopenia

0 (0)

17 (34.7)

13 (33.3)

ns

 Lymphopenia

1 (12.5)

18 (36.7)

25 (64.1)

p = 0.005

 Thrombocytopenia

1 (12.5)

9 (18.4)

12 (30.8)

ns

 Laboratory (%)

    

Low C3

3 (37.5)

41 (83.7)

34 (87.2)

p = 0.004

Low C4

3 (37.5)

42 (85.7)

34 (87.2)

p = 0.03

Autoantibodies positive :number (%)

    

ANA

8 (100)

46 (93.9)

36 (92.3)

ns

Anti-dsDNA antibody

5 (62.5)

44 (89.8)

30 (76.9)

ns

aCL

0/2 (0)

4/12 (33.3)

3/18 (16.7)

ns

LAC

0/2 (0)

1/13 (7.7)

1/18 (5.6)

ns

Anti-ENA

    

Anti-RNP

3/6 (50)

10/30 (33.3)

4/29 (13.8)

ns

Anti-Jo-1

1/6 (16.7)

0/30 (0)

0/29 (0)

p = 0.012

Anti-Scl-70

0/6 (0)

3/30 (10)

1/29 (3.4)

ns

Anti-Ro

4/6 (66.6)

10/30 (33.3)

11/29 (37.9)

ns

Anti-La

2/6 (33.3)

4/30 (13.3)

3/29(10.3)

ns

Anti-Sm

1/6 (16.7)

10/30 (33.3)

0/29 (0)

p = 0.009