Table 1 Clinical characteristics and laboratory investigation in KD patients with hemolytic anemia following IVIG
| Â | Case 1 | Case 2 | Case 3 | Case 4 |
|---|---|---|---|---|
Gender | Male | Female | Male | Male |
Age at diagnosis | 22 months | 4 years | 16 years | 7 months |
Duration of fever before treatment | 13 days | 9 days | 8 days | 5 days |
Clinical criteria of KD | 4/5 | 4/5 | 4/5 | 4/5 |
Hemoglobin (g/L) before 1 st IVIG | 94 (115-135) | 117 (115-155) | 114 (130-160) | 93 (105-135) |
Lowest hemoglobin (g/L) after 2 nd IVIG | 65 | 64 | 56 | 56 |
Blood group | A Rh(D) pos | A Rh(D) pos | B Rh(D) pos | AB Rh(D) pos |
Direct antiglobulin test baseline (IgG) | ND* | Negative | Negative | ND* |
Direct antiglobulin test after hemolysis (IgG) | Positive | Positive | Positive | Positive |
Antibody identified in red blood cell eluate | Anti-A | ND* | Anti-B | Anti-A, Anti-B |
LDH (U/L) | 660 (470-920) | 522 (142-297) | 1881 (340-750) | 495 (140-304) |
Indirect bilirubin (umol/L) | 12 (0-34) | 20 (0-34) | 55 (0-19) | 29 (0-34) |
Haptoglobin (0.69 - 1.96 g/L) | 3.44 | ND* | 0.06 | 0.38 |
Significant spherocytosis | Yes | Yes | Yes | Yes |
Reticulocyte count (0.2 - 2%) | 13.1 | 12.2 | 4.7 | 2.4 |
Blood transfusion | No | No | Yes | Yes |
Coronary outcome | CAA | Normal | Normal | CAA |