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Agreement between physicians and parents in rating functional ability of children with juvenile idiopathic arthritis

Abstract

Objective

To investigate concordance between physicians and parents in rating the degree of functional ability of children with juvenile idiopathic arthritis (JIA).

Methods

The attending physician and a parent were asked to rate independently the level of physical functioning of 155 patients with disease duration ≥ 5 years on a 6-point scale ranging from 1 = no disability (i.e. the child can do without difficulty all activities that children of his/her age can do) to 6 = severe disability (i.e. all activities are difficult for the child). At study visit, measures of JIA activity and damage were assessed. Agreement was evaluated with weighted kappa (<0.40 = poor agreement; 0.41–0.60 = moderate agreement; 0.61–0.80 = substantial agreement; >0.80 excellent agreement). Physician/parent evaluations were divided in 3 groups: 1) concordance; 2) parent over-rating = parent assessment over-rated relative to physician assessment; 3) physician over-rating = physician assessment over-rated relative to parent assessment. Factors affecting concordance/discordance were evaluated by means of Kruskal-Wallis or Chi-square/Fisher exact test.

Results

Concordance, parent over-rating and physician over-rating were observed in 107 (69%), 29 (18.7%) and 19 (12.3%) evaluations, respectively. Kappa value was 0.69. Parent over-rating was associated with greater intensity of pain (p = 0.01) and higher Childhood Health Assessment Questionnaire (C-HAQ) score (p = 0.004), whereas physician over-rating was associated with more severe joint disease (p = 0.04 to <0.001), higher C-reactive protein (p = 0.03) higher frequency of Steinbrocker functional class = II (p < 0.001), and greater articular damage, as measured with the Juvenile Arthritis Damage Index (p < 0.001).

Conclusion

Physicians and parents revealed fair concordance in rating functional ability of children with JIA. Parent over-rating was associated with greater child's pain and worse C-HAQ score, whereas physician over-rating was associated with greater severity of joint inflammation and damage.

Introduction

The assessment of functional ability is of primary importance in the clinical evaluation of children with juvenile idiopathic arthritis (JIA). Physical disability is a central domain of disease outcome as prevention of loss of function is one of the main aims of JIA treatment. In the past, the level of physical functioning was usually determined through the use of physician-centered measures, such as the Steinbrocker functional classification [1]. Starting in the 90s, parent-centered measures, such as parent-proxy report of physical functioning with questionnaires [28], achieved increasing popularity. Most of the recent long-term outcome studies in JIA (reviewed in 9 and 10) have incorporated both physician-centered and parent-centered functional ability measures. However, little is known about the extent to which physicians' and parents' reports of physical functioning agree. In all chronic conditions, the parent's and patient's expectations and definition of disease severity do not often coincide with those of the professionals caring for their children. We previously found that a sizable proportion of parents either under or overestimate the degree of their children's functional ability, as measured with the C-HAQ, when compared with the objective physician's assessment [11].

The agreement on defining the level of functional ability of children with JIA is an important aspect of physician-parent interaction in clinical practice. Since the improvement in physical function is of foremost importance to parents and the patient, and the achievement of a normal functional ability status may have major prognostic implications, it is important to ascertain whether parents' and clinicians' opinions converge or diverge and to identify the factors that may explain the discordance. Substantial disagreement between parents and physicians over physical function can lead to difficulty in assessing the effectiveness of therapy or in evaluating the need for additional interventions. Furthermore, poor clinician/parent concordance may lead to parent dissatisfaction and decreased compliance.

In the present study, we have investigated the agreement between physicians and parents in the assessment of functional ability of children with JIA and attempted to identify factors affecting discordance.

Methods

Patient selection

All consecutive patients seen at the study unit between September, 2002 and June, 2004 who had JIA by the International League of Associations for Rheumatology (ILAR) criteria [12] and had at least 5 years of disease duration were included in the study. Due to their peculiar clinical features, particularly the presence of enthesitis and reduced spinal mobility, patients with enthesitis-related arthritis (ERA) or juvenile ankylosing spondylitis were excluded. A further reason for exclusion was the lack of instruments specifically validated for use in these conditions. The study protocol was approved by the Ethic Committee of the Istituto Gaslini of Genova, Italy

Assessment of functional ability

The attending physician (AR or SV) and one parent (the mother, whenever available) were asked to rate independently the level of the child's functional ability on a 6-point categorical scale [13]. The question stem, "Considering the child's ability to do the activities of daily life, overall which describes he/she best?", prompted the respondent to choose from 6 response categories: 1 = no disability (i.e. the child can do all activities other children of his/her age can do with no problems); 2 = mild disability (i.e. the child can do almost all activities other children of his/her age can do with no problems); 3 = mild-to-moderate disability (the child can do most activities, but some activities are hard for him/her); 4 = moderate disability (the child can do most activities, but many activities are hard for him/her); 5 = moderate-to-severe disability (most activities are hard for the child); 6 = severe disability (all activities are hard for the child). The parents were instructed to consider the week before the study visit. The attending physicians were asked to base their judgment on their clinical impression at the time of the study visit. Beside the traditional physician-centered measures (see below), the physician assessed the ability of the child to perform some "core" functional activities (i.e. walking on flat ground and on tiptoes, squatting down, bending down, etc.) to get a general idea of the child's functional ability. Since all patients had long-standing disease, most of them were well known to the attending physician. Both attending physicians were pediatric rheumatologists with > 15 years' experience.

The same parent who provided the categorical rating of functional ability was also asked to complete the Italian version of the Childhood Health Assessment Questionnaire (C-HAQ) [14] (0 = best; 3 = worst). A second physician (EP or NS), who watched the clinical assessment of the attending physician, assigned independently the Steinbrocker functional classification [1]. Both these physicians were pediatric residents with > 2 years of training in pediatric rheumatology. Prior to the study initiation, they were instructed on the general clinical meaning and the scoring method of the Steinbrocker functional classification.

Clinical assessment

Patient general information included onset age, sex, and ILAR category. The following clinical measures of JIA activity were recorded at the study visit: physician's global assessment of the overall disease activity measured on a 10-cm visual analogue scale (VAS) (0 = no activity; 10 = maximum activity); parent's global assessment of the child's well-being on a 10-cm VAS (0 = very good; 10 = very poor); parent's rating of the intensity of the child's pain (0 = no pain; 10 = maximum pain); count of joints with swelling, pain on motion/tenderness, restricted motion, and active arthritis [15]; duration of morning stiffness; erythrocyte sedimentation rate (ESR) (Westergren method); C-reactive protein (CRP) (nephelometry). The amount of articular and extra-articular damage was measured through the articular and extra-articular components of the Juvenile Arthritis Damage Index (JADI-A and JADI-E, respectively) [16]. Briefly, the JADI-A assessed 36 joints or joint groups for the presence of damage and the damage observed in each joint is scored on a 3-point scale (0 = no damage; 1 = partial damage; 2 = severe damage, ankylosis, or prosthesis). The maximum total score is 72. The JADI-E includes 13 items in 5 different organ/systems. Each item is scored as 0 or 1 if damage is absent or present, respectively, except for damage in each eye, which is scored on a 0–3 scale. The maximum total score is 17. The child's health-related quality of life (HRQL) was assessed by the same parent who provided the categorical rating of functional ability through the Italian version of the Child Health Questionnaire (CHQ) [14]. Briefly, the CHQ is a generic health instrument designed to capture the physical and psychosocial functioning of children 5 years of age and older. It includes 50 items/questions and yields two summary scores, the physical score (PhS) and psychosocial score (PsS). The mean ± SD norm based score from cross-cultural general populations for both PhS and PsS is 50 ± 10, with higher scores indicating better health.

Radiographic assessment

Radiographic joint damage was scored according to the Poznanski method [17, 18]. Briefly, this method is based on the measurement of the radiometacarpal length (RM) and of the length of the second metacarpal bone (M2). For each wrist, the number of standard deviations (SD) between the expected and the observed RM for the measured M2 was calculated according to the formulae reported by Poznanski et al [17]. The RM/M2 ratio, which constitutes the Poznanski score, reflects the amount of radiographic damage in the wrist. The more negative the Poznanski score is, the more severe the radiographic damage. In each patient, the Poznanski score was expressed as the mean of the 2 wrists.

Statistics

Descriptive statistics were reported in terms of means, standard deviations, medians and upper and lower quartiles for continuous variables and in terms of absolute frequencies and percentages for categorical variables. Agreement between physicians and parents was evaluated with weighted kappa (<0.40 = poor agreement; 0.41–0.60 = moderate agreement; 0.61–0.80 = substantial agreement; >0.80 excellent agreement) [19]. Physician/parent evaluations were divided in 3 groups: 1) concordance = parent assessment equal to physician assessment; 2) parent over-rating = parent assessment over-rated relative to physician assessment; 3) physician over-rating = physician assessment over-rated relative to parent assessment. Comparison of quantitative variables among concordance/discordance groups was made by means of the non-parametric analysis of variance (Kruskal-Wallis test); the Dunn test was chosen as a posteriori test to assess the statistical significance of differences between pairs of patient groups. Comparison of qualitative data was performed by means of the χ2 test, or the Fisher Exact test in case of expected frequencies less than 5. Bonferroni adjustment was applied as a correction for multiple comparisons to explore post-hoc differences between pairs of patients groups. All statistical tests were two sided; a P value of less than 0.05 was considered as statistically significant. The statistical package used was the "Statistica" (StatSoft Corp., Tulsa, OK).

Results

A total of 155 patients, 35 males and 120 females, were included in the study. The ILAR category was systemic arthritis in 19 patients, rheumatoid factor (RF)-negative polyarthritis in 28 patients, RF-positive in 5 patients, persistent oligoarthritis in 42 patients, extended oligoarthritis in 41 patients, psoriatic arthritis in 5 patients, and undifferentiated arthritis in 15 patients. One-hundred-eighteen patients were antinuclear antibody-positive. All but 3 patients were of Italian ancestry. The much greater proportion of girls in our cohort is explained by the high prevalence of the ANA-positive subset of JIA in the Italian population. The main demographic and clinical features of the study patients are reported in Table 1. The values of the categorical disability scores are presented in table 2. None of the approached families declined to participate in the study. According to inclusion criteria, all patients had long-standing disease, with a minimum and median disease duration of 5 and 7.3 year, respectively. The median number of actively inflamed and functionally restricted joints (2 and 1, respectively) reflected moderate-to-low disease activity and severity. The median C-HAQ score of 0.3 meant that most children had mild disability. This is also reflected by the fact that only 3.9% of the patients were in Steinbrocker functional class III or IV and that 5% or less of the patients were in physician's or parent's categorical scale IV to VI.

Table 1 Demographic and clinical features of the 155 study patients
Table 2 Results of categorical assessments of functional ability

Concordance, parent over-rating and physician over-rating were observed in 107 (69%), 29 (18.7%) and 19 (12.3%) evaluations, respectively. The weighted kappa value was 0.69, meaning substantial agreement. Table 3 shows the comparison of demographic and clinical variables and measures of disease severity in the 3 discordance groups. The parent over-rating group included relatively less females (p = 0.02). There was a relatively greater proportion of patients with persistent oligoarthritis in the concordance group and of patients with polyarthritis in the physician over-rating group (p = 0.005). Parent over-rating was associated with greater intensity of pain (p = 0.01) and higher CHAQ score (p = 0.004), whereas physician over-rating was associated with greater severity of joint disease, as reflected by greater frequency of polyarticular involvement (i.e. ≥ 5 affected joints) and worse joint counts (p = 0.04 to <0.001), higher CRP (p = 0.03), higher frequency of Steinbrocker functional class = II (p < 0.001), and greater articular damage, as measured with the JADI (p < 0.001).

Table 3 Factors affecting concordance between physicians' and parents' assessment of functional ability. Values are medians (interquartile range) unless otherwise indicated

Discussion

In the present study, we found an overall fair agreement between the physicians and the parents in rating the level of functional ability of children with JIA, with more than two third of the evaluations being concordant. The weighted kappa value fell in the "substantial agreement" range. These findings are surprising because parents and physicians were measuring something different: the parent's rating was supposed to reflect the child's average performance over the preceding week, whereas the physicians were assessing the child at one point in time only. Furthermore, the parents were likely to base their judgment on the direct observation of the child's ability to perform activities in daily life, whereas the physicians had to rely on the findings of clinical assessment. The concordance seen in this study compares favorably with the level of agreement previously observed for other health assessments, such as C-HAQ disability, pain, disease activity, and disease remission [11, 2022]. In a past study that compared parent-proxy reported to physician-observed assessment of functional ability, as measured with the C-HAQ, we found that for only 43% of patients there was concordance [11]. In another analysis, we observed only a moderate agreement between parents and physicians in rating the intensity of children's pain [20]. When we investigated the discrepancy between physician's and parent's global assessments of disease status, we found that physicians and parents may perceive the health status of children with JIA differently, with parents providing more frequently lower rating [21]. We recently observed a frequent discordance between physicians and parents in rating the disease as inactive disease in children with JIA [22]. This indicated that a number of instances of physician-defined inactive disease may not be agreed upon by the parents. The greater agreement obtained with the administration of a 6-point categorical scale suggests that the use of simpler instruments may facilitate physician-parent concordance. However, the scale used in the study is not intended as a substitute for the more detailed and comprehensive instruments, such as the C-HAQ, which give the best information regarding children's functional ability. Furthermore, it should be acknowledged that the validity and reliability of the instrument used in the study were not formally assessed.

Discordance between the physicians and the parents was observed for 31% of patients. Among discordant evaluations, parent's over-rating relative to physician's assessment (i.e. the parent judged the level of child's physical function as worse than the physician) was seen more frequently than physician's over-rating relative to parent's assessment (i.e. the physician judged the level of child's physical function as worse than the parent). Parents judged child's functional ability as worse than physicians with greater intensity of the child' pain and with higher CHAQ score. Physicians judged child's functional ability as worse than the parents with greater severity of joint disease, higher CRP, higher frequency of Steinbrocker functional class ≥ II, and greater articular damage, as measured with the JADI. These findings suggest that the presence of pain may have a relevant influence on proxy-reported functional ability, leading the parents to potentially emphasize their child's disability. The relationship between the parents' categorical assessment and the C-HAQ score was expected because this questionnaire is a proxy-reported measure of the child's functional ability. That physicians' overestimation was associated with the physician-centered measures of joint inflammation or damage suggests that physicians tends to intuitively adjust the amount of impairment that they see to the objective signs of disease activity and joint impairment presented by the patient.

We must acknowledge that by describing the parent-physician discordance in rating the level of functional ability of children with JIA, we cannot imply that the physician's assessment is the right one. It is well known that parents and doctors may have widely different perspectives relating to their beliefs about health and illness, their expectations of medical care, their priorities for treatment and the ways in which they interpret information about child's disease [11]. It is likely that many other factors not primarily related to disease activity, such as psychosocial issues, may have a major influence on the parent's perception of the child's well-being [23, 24]. We asked the mothers to rate the health status of their children, but did not obtain information on children's self reporting. However, using only parent's proxy reports instead of both parent's and patient's self reports would fail to capture that parents and children may differ in their perception of health [20, 25]. A wide variation in agreement between adolescents with JIA and their parents about physical health, functional ability, and HRQL was recently reported [26]. Notably, the accuracy of the parents in reporting their children's functional ability lessens as children become adolescents and the parents no longer observe some activities. The low level of disease activity and disability in most of our patients may have limited the generalizability of our study. In addition, it might have facilitated the achievement of a concordance between raters. However, our patients represent a consecutive sampling of our clinic population and are likely representative of the patients seen in most tertiary pediatric rheumatology centers. It should be, recognized, however, that the exclusion of patients with ERA, which represent around 6% of our JIA population, may limit the generalizability of our findings. The much greater prevalence of females in our cohort might also affect the generalizability of our results.

In conclusion, we found that physicians and parents revealed an overall fair concordance in rating functional ability of children with JIA. Parent over-rating was associated with greater intensity of child's pain and worse C-HAQ disability, whereas physician-over rating was associated with greater severity of joint inflammation and damage.

References

  1. Steinbrocker O, Traeger CH, Battman RG: Therapeutic criteria in rheumatoid arthritis. J Am Med Assoc. 1949, 140: 659-62.

    Article  CAS  PubMed  Google Scholar 

  2. Ravelli A, Viola S, Ramenghi B, Di Fuccia G, Ruperto N, Zonta L, Martini A: Evaluation of response to methotrexate by a functional index in juvenile chronic arthritis. Clin Rheumatol. 1995, 14: 322-6. 10.1007/BF02208347.

    Article  CAS  PubMed  Google Scholar 

  3. Howe S, Levinson J, Shear E, Hartner S, McGirr G, Schulte M, Lovell D: Development of a disability measurement tool for juvenile rheumatoid arthritis. The Juvenile Arthritis Functional Assessment Report for children and their parents. Arthritis Rheum. 1991, 34: 873-80. 10.1002/art.1780340713.

    Article  CAS  PubMed  Google Scholar 

  4. Singh G, Athreya BH, Fries JF, Goldsmith DP: Measurement of health status in children with juvenile rheumatoid arthritis. Arthritis Rheum. 1994, 37: 1761-9. 10.1002/art.1780371209.

    Article  CAS  PubMed  Google Scholar 

  5. Wright FV, Longo Kimber J, Law M, Goldsmith CH, Crombie V, Dent P: The Juvenile Arthritis Functional Status Index (JASI): a validation study. J Rheumatol. 1996, 23: 1066-79.

    CAS  PubMed  Google Scholar 

  6. Iglesias MJ, Cuttica RJ, Herrera Calvo M, Micelotta M, Brusco MI, Duran P: Design and validation of a new scale to assess the functional ability in children with juvenile idiopathic arthritis (JIA). Clin Exp Rheumatol. 2006, 24: 713-8.

    CAS  PubMed  Google Scholar 

  7. Duffy CM: Measurement of health status, functional status, and quality of life in children with juvenile idiopathic arthritis: clinical science for the pediatrician. Pediatr Clin North Am. 2005, 52: 359-72. 10.1016/j.pcl.2005.01.009.

    Article  PubMed  Google Scholar 

  8. Filocamo G, Sztajnbok F, Cespedes-Cruz A, Magni-Manzoni S, Pistorio A, Viola S, Ruperto N, Buoncompagni A, Loy A, Martini A, Ravelli A: Development and validation of a new short and simple measure of physical function for juvenile idiopathic arthritis. Arthritis Rheum. 2007, 57: 913-920. 10.1002/art.22900.

    Article  PubMed  Google Scholar 

  9. Oen K: Long-term outcomes and predictors of outcomes for patients with juvenile idiopathic arthritis. Best Pract Res Clin Rheumatol. 2002, 16: 347-60.

    Article  PubMed  Google Scholar 

  10. Ravelli A: Toward an understanding of the long-term outcome of juvenile idiopathic arthritis. Clin Exp Rheumatol. 2004, 22: 271-5.

    CAS  PubMed  Google Scholar 

  11. Ravelli A, Viola S, Migliavacca D, Pistorio A, Ruperto N, Martini A: Discordance between proxy-reported and observed assessment of functional ability of children with juvenile idiopathic arthritis. Rheumatology. 2001, 40: 914-9. 10.1093/rheumatology/40.8.914.

    Article  CAS  PubMed  Google Scholar 

  12. Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, He X, Maldonado-Cocco J, Orozco-Alcala J, Prieur AM, Suarez-Almazor ME, Woo P, International League of Associations for Rheumatology: International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton 2001. J Rheumatol. 2004, 31: 390-2.

    PubMed  Google Scholar 

  13. Dempster H, Porepa M, Young N, Feldman BM: The clinical meaning of functional outcome scores in children with juvenile arthritis. Arthritis Rheum. 2001, 44: 1768-74. 10.1002/1529-0131(200108)44:8<1768::AID-ART312>3.0.CO;2-Q.

    Article  CAS  PubMed  Google Scholar 

  14. Ruperto N, Ravelli A, Pistorio A, Malattia C, Viola S, Cavuto S, Alessio M, Alpigiani MG, Buoncompagni A, Corona F, Cortis E, Falcini F, Gerloni V, Lepore L, Sardella ML, Strano CG, Zulian F, Gado-West L, Tortorelli A, Fantini F, Martini A, Paediatric Rheumatology International Trials Organisation: The Italian version of the Childhood Health Assessment Questionnaire (CHAQ) and the Child Health Questionnaire (CHQ). Clin Exp Rheumatol. 2001, 19 (4 Suppl 23): S91-S95.

    CAS  PubMed  Google Scholar 

  15. Ravelli A, Viola S, Ruperto N, Corsi B, Ballardini G, Martini A: Correlation between conventional disease activity measures in juvenile chronic arthritis. Ann Rheum Dis. 1997, 56: 197-200.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Viola S, Felici E, Magni-Manzoni S, Pistorio A, Buoncompagni A, Ruperto N, Rossi F, Bartoli M, Martini A, Ravelli A: Development and validation of a clinical index for assessment of long-term damage in juvenile idiopathic arthritis. Arthritis Rheum. 2005, 52: 2092-102. 10.1002/art.21119.

    Article  PubMed  Google Scholar 

  17. Poznanski AK, Hernandez RJ, Guire KE, Bereza U, Garn SM: Carpal length in children – A useful measurement in the diagnosis of rheumatoid arthritis and some congenital malformation syndromes. Radiology. 1978, 129: 661-8.

    Article  CAS  PubMed  Google Scholar 

  18. Magni-Manzoni S, Rossi F, Pistorio A, Temporini F, Viola S, Beluffi G, Martini A, Ravelli A: Prognostic factors for radiographic progression, radiographic damage and disability in juvenile idiopathic arthritis. Arthritis Rheum. 2003, 48: 3509-17. 10.1002/art.11337.

    Article  PubMed  Google Scholar 

  19. Cohen J: Weighted kappa: nominal scale agreement with provision for scaled disagreement or partial credit. Psychological bulletin. 1968, 70: 213-220. 10.1037/h0026256.

    Article  CAS  PubMed  Google Scholar 

  20. Garcia-Munitis P, Bandeira M, Pistorio A, Magni-Manzoni S, Ruperto N, Schivo A, Martini A, Ravelli A: Level of agreement between children, parents, and physicians in rating pain intensity in juvenile idiopathic arthritis. Arthritis Rheum. 2006, 55: 177-83. 10.1002/art.21840.

    Article  PubMed  Google Scholar 

  21. Sztajnbok F, Coronel-Martinez DL, Diaz-Maldonado A, Novarini C, Pistorio A, Viola S, Ruperto N, Buoncompagni A, Martini A, Ravelli A: Discordance between physician's and parent's global assessments in juvenile idiopathic arthritis. Rheumatology. 2007, 46: 141-145. 10.1093/rheumatology/kel201.

    Article  CAS  PubMed  Google Scholar 

  22. Consolaro A, Vitale R, Pistorio A, Lattanzi B, Ruperto N, Malattia C, Filocamo G, Viola S, Martini A, Ravelli A: Physician's and parent's ratings of inactive disease are frequently discordant in juvenile idiopathic arthritis. J Rheumatol. 2007, 34: 1773-6.

    PubMed  Google Scholar 

  23. Antony KK, Schanberg LE: Pain in children with arthritis: a review of the current literature. Arthritis Rheum. 2003, 49: 272-9. 10.1002/art.11010.

    Article  Google Scholar 

  24. Duffy CM: health outcomes in pediatric rheumatic diseases. Curr Opin Rheumatol. 2004, 16: 102-8. 10.1097/00002281-200403000-00005.

    Article  PubMed  Google Scholar 

  25. Brunner HI, Klein-Gitelman MS, Miller MJ, Trombley M, Baldwin N, Kress A, Johnson AL, Barron AC, Griffin TA, Passo MH, Lovell DJ: Health of children with chronic arthritis: relationship of different measures and the quality of parent proxy reporting. Arthritis Rheum. 2004, 51: 763-73. 10.1002/art.20689.

    Article  PubMed  Google Scholar 

  26. Shaw KL, Southwood TR, McDonagh JE: Growing up and moving on in rheumatology: parents as proxies of adolescents with juvenile idiopathic arthritis. Arthritis Rheum. 2006, 55: 189-98. 10.1002/art.21834.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Angelo Ravelli.

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Authors' contributions

AR conceived the study, and participated in its design and coordination, and in manuscript preparation. NR, SV and AM participated in the design of the study, and in the analysis and interpretation of data. AM participated in manuscript preparation. EP, NS, CM, SV, AB and AL participated in the acquisition of data. AP performed the statistical analysis. All authors have read and approved the final manuscript.

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Palmisani, E., Solari, N., Pistorio, A. et al. Agreement between physicians and parents in rating functional ability of children with juvenile idiopathic arthritis. Pediatr Rheumatol 5, 23 (2007). https://doi.org/10.1186/1546-0096-5-23

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